{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:43:46Z","timestamp":1775576626050,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Angiogenesis is disrupted in age\u2010related and postmenopausal osteoporosis. However, the mechanisms of the disorder remain elusive. We confirmed in this study that, in accordance with the decrease of H\u2010type vessels, the proangiogenic potential of bone marrow\u2010derived mesenchymal stem cells (BMSCs) declined during osteoporosis. Screening of the histone acetyltransferase family revealed that GCN5 decreased in BMSCs derived from osteoporotic femur. Further analysis identified that GCN5 plays important roles in regulating the proangiogenic potential of BMSCs. GCN5 promoted BMSC\u2010mediated angiogenesis by enhancing H3K9ac levels on the promoter of\n                    <jats:italic>Vegf<\/jats:italic>\n                    . The decrease of GCN5 in osteoporotic BMSCs led to the decline of proangiogenic capacity. Accordingly, overexpression of GCN5 enhanced the proangiogenic potency of osteoporotic BMSCs. Furthermore, recovering GCN5 expression\n                    <jats:italic>in vivo<\/jats:italic>\n                    by lentiviral expression vector significantly attenuated the loss of angiogenesis in ovariectomized mouse femurs. Our study results revealed an epigenetic mechanism controlling BMSC\u2010mediated angiogenesis and provided a novel therapeutic target for osteoporosis treatment.\u2014Jing, H., Liao, L., Su, X., Shuai, Y. Zhang, X., Deng, Z., Jin, Y. Declining histone acetyltransferase GCN5 represses BMSC\u2010mediated angiogenesis during osteoporosis. FASEB J. 31, 4422\u20134433 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700118r","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T20:30:21Z","timestamp":1498163421000},"page":"4422-4433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Declining histone acetyltransferase GCN5 represses BMSC\u2010mediated angiogenesis during osteoporosis"],"prefix":"10.1096","volume":"31","author":[{"given":"Huan","family":"Jing","sequence":"first","affiliation":[{"name":"State Key Laboratory of Military Stomatology Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"National Clinical Research Center for Oral Diseases Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"National Clinical Research Center for Oral Diseases Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Su","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shuai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"National Clinical Research Center for Oral Diseases Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Prothodontics Stomatological Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"National Clinical Research Center for Oral Diseases Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology Xijing Hospital Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050917"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01654"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1302\/0301-620X.45B3.572","article-title":"The vascular contribution to osteogenesis, V: the vasculature supplying the epiphysial cartilage in rachitic rats","volume":"45","author":"Trueta J.","year":"1963","journal-title":"J. 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