{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T17:49:26Z","timestamp":1771350566456,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Structural changes known as airway remodeling (AWR) characterize chronic\/severe asthma and contribute to lung dysfunction. Thus, we assessed the\n                    <jats:italic>in vivo<\/jats:italic>\n                    efficacy of induced pluripotent stem cell and mesenchymoangioblast\u2010derived mesenchymal stem cells (MCA\u2010MSCs) on AWR in a murine model of chronic allergic airways disease (AAD)\/asthma. Female Balb\/c mice were subjected to a 9\u2010wk model of ovalbumin (Ova)\u2010induced chronic AAD and treated intravenously or intranasally with MCA\u2010MSCs from weeks 9 to 11. Changes in airway inflammation (AI), AWR, and airway hyperresponsiveness (AHR) were assessed. Ova\u2010injured mice presented with AI, goblet cell metaplasia, epithelial thickening, increased airway TGF\u2010\u03b21 levels, subepithelial myofibroblast and collagen accumulation, total lung collagen concentration, and AHR (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001\n                    <jats:italic>vs.<\/jats:italic>\n                    uninjured control group). Apart from epithelial thickness, all other parameters measured were significantly, although not totally, decreased by intravenous delivery of MCA\u2010MSCs to Ova\u2010injured mice. In comparison, intranasal delivery of MCA\u2010MSCs to Ova\u2010injured mice significantly decreased all parameters measured (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05\n                    <jats:italic>vs.<\/jats:italic>\n                    Ova group) and, most notably, normalized aberrant airway TGF\u2010\u03b21 levels, airway\/lung fibrosis, and AHR to values measured in uninjured animals. MCA\u2010MSCs also increased collagen\u2010degrading gelatinase levels. Hence, direct delivery of MCA\u2010MSCs offers great therapeutic benefit for the AWR and AHR associated with chronic AAD.\u2014Royce, S. G., Rele, S., Broughton, B. R. S., Kelly, K., Samuel, C. S. Intranasal administration of mesenchymoangioblast\u2010derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease. FASEB J. 31, 4168\u20134178 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                    \u2014Royce, Simon G., Rele, Siddharth, Broughton, Brad R. S., Kelly, Kilian, Samuel, Chrishan S., Intranasal administration of mesenchymoangioblast\u2010derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease. 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