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Its canonical target, mammalian target of rapamycin complex 1 (mTORC1), plays a key role in metabolism and binds chromatin; however, its precise role in the male germline has not been elucidated. Here, we inactivate the core component, Raptor, to show that mTORC1 function is critical for male meiosis and the inactivation of sex chromosomes. Disruption of the\n                    <jats:italic>Raptor<\/jats:italic>\n                    gene impairs chromosomal synapsis and prevents the efficient spreading of silencing factors into the XY chromatin. Accordingly, mRNA for XY\u2010linked genes remains inappropriately expressed in\n                    <jats:italic>Raptor<\/jats:italic>\n                    \u2010deficient mice. Molecularly, the failure to suppress gene expression corresponded with deficiencies in 2 repressive chromatin markers, H3K9 dimethylation and H3K9 trimethylation, in the XY body. Together, these results demonstrate that mTORC1 has an essential role in the meiotic progression and silencing of sex chromosomes in the male germline, which may explain the infertility that has been associated with such inhibitors as rapamycin.\u2014Xiong, M., Zhu, Z., Tian, S., Zhu, R., Bai, S., Fu, K., Davis, J. G., Sun, Z., Baur, J. A., Zheng, K., Ye, L. Conditional ablation of Raptor in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes. FASEB J. 31, 3934\u20133949 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                    \u2014Xiong, Mengneng, Zhu, Zhiping, Tian, Suwen, Zhu, Ruping, Bai, Shun, Fu, Kaiqiang, Davis, James G., Sun, Zheng, Baur, Joseph A., Zheng, Ke, Ye, Lan, Conditional ablation of\n                    <jats:italic>Raptor<\/jats:italic>\n                    in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes. FASEB J. 31, 3934\u20133949 (2017)\n                  <\/jats:p>","DOI":"10.1096\/fj.201700251r","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T10:07:59Z","timestamp":1494497279000},"page":"3934-3949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Conditional ablation of\n                    <i>Raptor<\/i>\n                    in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes"],"prefix":"10.1096","volume":"31","author":[{"given":"Mengneng","family":"Xiong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiping","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing 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