{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:06:04Z","timestamp":1786550764795,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>\n                    Male sex hormones\u2014androgens\u2014regulate male physique development. Without androgen signaling, genetic males appear female. During puberty, increasing androgens harness the hair follicle's unique regenerative ability to replace many tiny vellus hairs with larger, darker terminal hairs (\n                    <jats:italic>e.g.<\/jats:italic>\n                    , beard). Follicle response is epigenetically varied: some remain unaffected (\n                    <jats:italic>e.g.<\/jats:italic>\n                    , eyelashes) or are inhibited, causing balding. How sex steroid hormones alter such developmental processes is unclear, despite high incidences of hormone\u2010driven cancer, hirsutism, and alopecia. Unfortunately, existing development models are not androgen sensitive. Here, we use hair follicles to establish an androgen\u2010responsive human organ culture model. We show that women's intermediate facial follicles respond to men's higher androgen levels by synthesizing more hair over several days, unlike donor\u2010matched, androgen\u2010insensitive, terminal follicles. We demonstrate that androgen receptors\u2014androgen\u2010activated gene transcription regulators\u2014are required and are present\n                    <jats:italic>in vivo<\/jats:italic>\n                    within these follicles. This is the first human organ that involves multiple cell types that responds appropriately to hormones in prolonged culture, in a way which mirrors its natural behavior. Thus, intermediate hair follicles offer a hormone\u2010switchable human model with exceptional, unique availability of genetically identical, but epigenetically hormone\u2010insensitive, terminal follicles. This should enable advances in understanding sex steroid hormone signaling, gene regulation, and developmental and regenerative systems and facilitate better therapies for hormone\u2010dependent disorders.\u2014Miranda, B. H., Charlesworth, M. R., Tobin, D.J., Sharpe, D.T., Randall, V. A. Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    32, 795\u2013806 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700260rr","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T18:00:13Z","timestamp":1508349613000},"page":"795-806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life"],"prefix":"10.1096","volume":"32","author":[{"given":"Benjamin H.","family":"Miranda","sequence":"first","affiliation":[{"name":"Centre for Skin Sciences University of Bradford Bradford United Kingdom"},{"name":"Plastic Surgery and Burns Research Unit University of Bradford Bradford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Charlesworth","sequence":"additional","affiliation":[{"name":"Centre for Skin Sciences University of Bradford Bradford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desmond J.","family":"Tobin","sequence":"additional","affiliation":[{"name":"Centre for Skin Sciences University of Bradford Bradford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Centre for Skin Sciences University of Bradford Bradford United Kingdom"},{"name":"Plastic Surgery and Burns Research Unit University of Bradford Bradford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.","family":"Randall","sequence":"additional","affiliation":[{"name":"Centre for Skin Sciences University of Bradford Bradford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1324728"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs153"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4832-3287-4.50022-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2007.02.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1017\/CBO9781139003353.008","volume-title":"Testosterone: Action, Deficiency, Substitution","author":"Randall V. 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