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Indeed, ODC is the target of the WHO \u201cessential medicine\u201d eflornithine, which is antagonistic to another anti\u2010HAT drug, suramin. Thus, ornithine uptake has important consequences in\n                    <jats:italic>T. brucei<\/jats:italic>\n                    , but the transporters have not been identified. We describe these amino acid transporters (AATs). In a heterologous expression system, TbAAT10\u20101 is selective for ornithine, whereas TbAAT2\u20104 transports both ornithine and histidine. These AATs are also necessary to maintain intracellular ornithine and polyamine levels in\n                    <jats:italic>T. brucei<\/jats:italic>\n                    , thereby decreasing sensitivity to eflornithine and increasing sensitivity to suramin. Consistent with competition for histidine, high extracellular concentrations of this amino acid phenocopied a TbAAT2\u20104 genetic defect. Our findings established TbAAT10\u20101 and TbAAT2\u20104 as the parasite ornithine transporters, one of which can be modulated by histidine, but both of which affect sensitivity to important anti\u2010HAT drugs.\u2014Macedo, J. P., Currier, R. B., Wirdnam, C., Horn, D., Alsford, S., Rentsch, D. Ornithine uptake and the modulation of drug sensitivity in\n                    <jats:italic>Trypanosoma brucei.<\/jats:italic>\n                    FASEB J. 31, 4649\u20134660 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700311r","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T21:10:18Z","timestamp":1499289018000},"page":"4649-4660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ornithine uptake and the modulation of drug sensitivity in\n                    <i>Trypanosoma brucei<\/i>"],"prefix":"10.1096","volume":"31","author":[{"given":"Juan P.","family":"Macedo","sequence":"first","affiliation":[{"name":"Institute of Plant Sciences University of Bern Bern 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