{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:41:38Z","timestamp":1777088498690,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>\n                    We found that the orally administered thermolysin digest of \u03b2\u2010conglycinin exhibits antidepressant\u2010like effects in tail suspension and forced swim tests in mice. A comprehensive peptide analysis of the digest using liquid chromatography\/mass spectrometry was performed, and LSSTQAQQSY emerged as a candidate antidepressant\u2010like peptide. Orally administered synthetic LSSTQAQQSY exhibited antidepressant\u2010like effects at a dose of 0.3 mg\/kg; therefore, we named the decapeptide soy\u2010deprestatin. In contrast, intraperitoneally administered soy\u2010deprestatin was ineffective. We then hypothesized that it acted on the gut, and its signal was transferred to the brain. Indeed, orally administered soy\u2010deprestatin exhibited antidepressant\u2010like activity in sham\u2010treated, but not vagotomized, mice. Oral administration of soy\u2010deprestatin also increased the c\u2010Fos expression in the nucleus of the solitary tract, which receives inputs from the vagus nerve. These results suggested that the antidepressant\u2010like effects were mediated by the vagus nerve. Thermolysin digest\u2010 and soy\u2010deprestatin\u2013induced antidepressant\u2010like effects were also blocked by antagonists of serotonin 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    , dopamine D\n                    <jats:sub>1<\/jats:sub>\n                    , or GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors. We also clarified the order of receptor activation as 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    , D\n                    <jats:sub>1<\/jats:sub>\n                    , and GABA\n                    <jats:sub>A<\/jats:sub>\n                    , using selective agonists and antagonists. Taken together, soy\u2010deprestatin may exhibit antidepressant\u2010like effects after oral administration\n                    <jats:italic>via<\/jats:italic>\n                    a novel pathway mediated by 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    , followed by D\n                    <jats:sub>1<\/jats:sub>\n                    and GABA\n                    <jats:sub>A<\/jats:sub>\n                    systems. This is the first orally active peptide demonstrating antidepressant\u2010like effects\n                    <jats:italic>via<\/jats:italic>\n                    gut\u2013brain communication.\u2014Mori, Y., Asakura, S., Yamamoto, A., Odagiri, S., Yamada, D., Sekiguchi, M., Wada, K., Sato, M., Kurabayashi, A., Suzuki, H., Kanamoto, R., Ohinata, K. Characterization of soy\u2010deprestatin, a novel orally active decapeptide that exerts antidepressant\u2010like effects\n                    <jats:italic>via<\/jats:italic>\n                    gut\u2013brain communication.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    32, 568\u2013575 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700333rr","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T20:25:18Z","timestamp":1506975918000},"page":"568-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Characterization of soy\u2010deprestatin, a novel orally active decapeptide that exerts antidepressant\u2010like effects\n                    <i>via<\/i>\n                    gut\u2013brain communication"],"prefix":"10.1096","volume":"32","author":[{"given":"Yukiha","family":"Mori","sequence":"first","affiliation":[{"name":"Division of Food Science and Biotechnology Graduate School of Agriculture Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saho","family":"Asakura","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology Graduate School of Agriculture Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akane","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology Graduate School of Agriculture Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Odagiri","sequence":"additional","affiliation":[{"name":"Department of Degenerative Neurological Diseases National Institute of Neuroscience National Center of Neurology and Psychiatry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Degenerative Neurological Diseases National Institute of Neuroscience National Center of Neurology and Psychiatry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Degenerative Neurological Diseases National Institute of Neuroscience National Center of Neurology and Psychiatry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Degenerative Neurological Diseases National Institute of Neuroscience National Center of Neurology and Psychiatry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Research and Development Kazusa DNA Research Institutes Kisarazu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kurabayashi","sequence":"additional","affiliation":[{"name":"Department of Research and Development Kazusa DNA Research Institutes Kisarazu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Research and Development Kazusa DNA Research Institutes Kisarazu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuhei","family":"Kanamoto","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology Graduate School of Agriculture Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kousaku","family":"Ohinata","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology Graduate School of Agriculture Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization. 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