{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:05:31Z","timestamp":1789560331041,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB685"],"award-info":[{"award-number":["SFB685"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB766"],"award-info":[{"award-number":["SFB766"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR156"],"award-info":[{"award-number":["TRR156"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PE805\/5\u20101"],"award-info":[{"award-number":["PE805\/5\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Leukocytes express formyl\u2010peptide receptors (FPRs), which sense microbe\u2010associated molecular pattern (MAMP) molecules, leading to leukocyte chemotaxis and activation. We recently demonstrated that phenol\u2010soluble modulin (PSM) peptides from highly pathogenic\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    are efficient ligands for the human FPR2. How PSM detection by FPR2 impacts on the course of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>aureus<\/jats:italic>\n                    infections has remained unknown. We characterized the specificity of mouse FPR2 (mFpr2) using a receptor\u2010transfected cell line, homeobox b8 (Hoxb8), and primary neutrophils isolated from wild\u2010type (WT) or mFpr2\n                    <jats:sup>_\/_<\/jats:sup>\n                    mice. The influx of leukocytes into the peritoneum of WT and mFpr2\n                    <jats:sup>_\/_<\/jats:sup>\n                    mice was analyzed. We demonstrate that mFpr2 is specifically activated by PSMs in mice, and they represent the first secreted pathogen\u2010derived ligands for the mFpr2. Intraperitoneal infection with\n                    <jats:italic>S. aureus<\/jats:italic>\n                    led to lower numbers of immigrated leukocytes in mFpr2\n                    <jats:sup>_\/_<\/jats:sup>\n                    compared with WT mice at 3 h after infection, and this difference was not observed when mice were infected with an\n                    <jats:italic>S. aureus<\/jats:italic>\n                    PSM mutant. Our data support the hy\u2010pothesis that the mFpr2 is the functional homolog of the human FPR2 and that a mouse infection model represents a suitable model for analyzing the role of PSMs during infection. PSM recognition by mFpr2 shapes leukocyte influx in local infections, the typical infections caused by\n                    <jats:italic>S. aureus.<\/jats:italic>\n                    \u2014Weiss, E., Hanzelmann, D., Fehlhaber, B., Klos, A., von Loewenich, F. D., Liese, J., Peschel, A., Kretschmer, D. Formyl\u2010peptide receptor 2 governs leukocyte influx in local\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    infections. FASEB J. 32, 26\u201036 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700441r","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T20:50:18Z","timestamp":1504126218000},"page":"26-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Formyl\u2010peptide receptor 2 governs leukocyte influx in local\n                    <i>Staphylococcus aureus<\/i>\n                    infections"],"prefix":"10.1096","volume":"32","author":[{"given":"Elisabeth","family":"Weiss","sequence":"first","affiliation":[{"name":"Infection Biology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Hanzelmann","sequence":"additional","affiliation":[{"name":"Infection Biology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Fehlhaber","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Hygiene, Interfaculty Institute for Microbiology and Infection Medicine T\u00fcbingen (IMIT) University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Klos","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Hygiene, Interfaculty Institute for Microbiology and Infection Medicine T\u00fcbingen (IMIT) University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike D.","family":"von Loewenich","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Epidemiology Medical School Hannover Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Liese","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Hygiene, Medical Center University of Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Peschel","sequence":"additional","affiliation":[{"name":"Infection Biology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Kretschme","sequence":"additional","affiliation":[{"name":"Infection Biology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"e_1_2_23_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2008.09.012"},{"key":"e_1_2_23_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3521"},{"key":"e_1_2_23_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200423825"},{"key":"e_1_2_23_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3390"},{"key":"e_1_2_23_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.626747"},{"key":"e_1_2_23_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.05.012"},{"key":"e_1_2_23_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-175208"},{"key":"e_1_2_23_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12304"},{"key":"e_1_2_23_10_1","first-page":"1510","article-title":"Identification of novel cytolytic peptides as key virulence determinants for community\u2010associated MRSA Nat","volume":"13","author":"Wang R.","year":"2007","journal-title":"Med."},{"key":"e_1_2_23_11_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.2A0514-275R"},{"key":"e_1_2_23_12_1","first-page":"119","article-title":"International Union of Basic and Clinical Pharmacology","volume":"61","author":"Ye R. 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