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Recruited monocytes clear necrotic cardiomyocytes and differentiate into cardiac macrophages. Some studies have linked apoptotic cell receptors on cardiac macrophages to tissue repair; however' the contribution of precursor monocyte phagocytic receptors' which are the first to interact with the cardiac parenchyma' is unclear. The scavenger receptor cluster of differentiation (CD)36 protein was detected on cardiac Ly6cHI monocytes, and bone marrow\u2010derived\n                    <jats:italic>Cd36<\/jats:italic>\n                    was essential for both early phagocytosis of dying cardiomyocytes and for smaller infarct sizes in female and male mice after permanent coronary ligation.\n                    <jats:italic>Cd36<\/jats:italic>\n                    deficiency led to reduced expression of phagocytosis receptor\n                    <jats:italic>Mertk<\/jats:italic>\n                    and nuclear receptor\n                    <jats:italic>Nr4a1<\/jats:italic>\n                    in cardiac macrophages, the latter previously shown to be required for phagocyte survival.\n                    <jats:italic>Nr4a1<\/jats:italic>\n                    was required for phagocytosis\u2010induced\n                    <jats:italic>Mertk<\/jats:italic>\n                    expression, and Nr4a1 protein directly bound to\n                    <jats:italic>Mertk<\/jats:italic>\n                    gene regulatory elements. To test the overall contribution of the\n                    <jats:italic>Cd36\u2010Mertk<\/jats:italic>\n                    axis, MI was induced in\n                    <jats:italic>Cd36<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <jats:bold>\n                      <jats:italic>Mertk<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    double\u2010knockout mice and led to increases in myocardial rupture. These data implicate monocyte CD36 in the mitigation of early infarct size and transition to\n                    <jats:italic>Mertk<\/jats:italic>\n                    \u2010dependent macrophage function. Increased myocardial rupture in the absence of both\n                    <jats:italic>Cd36<\/jats:italic>\n                    and\n                    <jats:italic>Mertk<\/jats:italic>\n                    underscore the physiologic significance of phagocytosis during tissue injury.\u2014Dehn, S., Thorp, E. B. Myeloid receptor CD36 is required for early phagocytosis of myocardial infarcts and induction of Nr4a1\u2010dependent mechanisms of cardiac repair. FASEB J. 32,254\u2010264 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700450r","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T20:40:31Z","timestamp":1504212031000},"page":"254-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Myeloid receptor CD36 is required for early phagocytosis of myocardial infarcts and induction of Nr4a1\u2010dependent mechanisms of cardiac repair"],"prefix":"10.1096","volume":"32","author":[{"given":"Shirley","family":"Dehn","sequence":"first","affiliation":[{"name":"Department of Pathology Northwestern University Chicago Illinois USA"},{"name":"Feinberg Cardiovascular Research Institute, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Thorp","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Chicago Illinois USA"},{"name":"Feinberg Cardiovascular Research Institute, Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192666"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2012.11.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163111"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.06.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070885"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000130526.20854.fa"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303204"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020857"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301198"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32660"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"29601","DOI":"10.1038\/srep29601","article-title":"Nanoparticle\u2010mediated delivery ofirbesartan induces cardioprotection from myocardial ischemia\u2010reperfusion injury by antagonizing monocyte\u2010mediated inflammation","volume":"6","author":"Nakano Y.","year":"2016","journal-title":"Sci. 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