{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:27:40Z","timestamp":1778254060984,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>\n                    CD36 is a multiligand receptor involved in lipid metabolism. We investigated the mechanisms underlying the cardioprotective effect of CP\u20103(iv), an azapeptide belonging to a new class of selective CD36 ligands. The role of CP\u20103(iv) in mediating cardioprotection was investigated because CD36 signaling leads to activation of peroxisome proliferator\u2013activated receptor\u2010\u03b3, a transcriptional regulator of adiponectin. CP\u20103(iv) pretreatment reduced infarct size by 54% and preserved hemodynamics in C57BL\/6 mice subjected to 30 min coronary ligation and reperfusion but had no effect in CD36\u2010deficient mice. The effects of CP\u20103(iv) were associated with an increase in circulating adiponectin levels, epididymal fat adiponectin gene expression, and adiponectin transcriptional regulators (\n                    <jats:italic>Pparg, Cebpb, Sirt1<\/jats:italic>\n                    ) after 6 h of reperfusion. Reduced myocardial oxidative stress and apoptosis were observed along with an increase in expression of myocardial adiponectin target proteins, including cyclooxygenase\u20102, phospho\u2010AMPK, and phospho\u2010Akt. Moreover, CP\u20103(iv) increased myocardial performance in isolated hearts, whereas blockade of adiponectin with an anti\u2010adiponectin antibody abrogated it. CP\u20103(iv) exerts cardioprotection against myocardial ischemia and reperfusion (MI\/R) injury and dysfunction, at least in part, by increasing circulating and myocardial adiponectin levels. Hence, both paracrine and endocrine effects of adiponectin may contribute to reduced reactive oxygen species generation and apoptosis after MI\/R, in a CD36\u2010dependent manner.\u2014Huynh, D. N., Bessi, V. L., M\u00e9nard, L., Piquereau, J., Proulx, C., Febbraio, M., Lubell, W. D., Carpentier, A. C., Burelle, Y., Ong, H., Marleau, S. Adiponectin has a pivotal role in the cardioprotective effect of CP\u20103(iv), a selective CD36 azapeptide ligand, after transient coronary artery occlusion in mice.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    32, 807\u2013818 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700505r","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T21:00:23Z","timestamp":1507669223000},"page":"807-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Adiponectin has a pivotal role in the cardioprotective effect of CP\u20103(iv), a selective CD36 azapeptide ligand, after transient coronary artery occlusion in mice"],"prefix":"10.1096","volume":"32","author":[{"given":"David N.","family":"Huynh","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie L.","family":"Bessi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliane","family":"M\u00e9nard","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Piquereau","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"},{"name":"Universit\u00e9 Paris\u2010Sud 11 Orsay France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Proulx","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"},{"name":"North Carolina State University Raleigh NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Febbraio","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Lubell","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 C.","family":"Carpentier","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Medicine Universit\u00e9 de Sherbrooke Sherbrooke Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Burelle","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"},{"name":"University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huy","family":"Ong","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Marleau","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu299"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1378\/chest.11-2521","article-title":"Advancing cardiovascular research","volume":"141","author":"Lauer M. S.","year":"2012","journal-title":"Chest"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00266-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016602.96363.36"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.1.H290"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e328339f191"},{"key":"e_1_2_8_9_1","first-page":"290","article-title":"Targets for modulation of fatty acid oxidation in the heart","volume":"5","author":"Lopaschuk G. D.","year":"2004","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.272re3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2012.04.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.07.020"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs225"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20354"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm300557t"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1699"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1017"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1295"},{"key":"e_1_2_8_19_1","first-page":"253","article-title":"The cardio\u2010protective signaling and mechanisms of adiponectin","volume":"2","author":"Nanayakkara G.","year":"2012","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00522.2010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100320200"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.032"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20120060"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1253\/circj.66.819","article-title":"CD36 genotype and long\u2010chain fatty acid uptake in the heart","volume":"66","author":"Kintaka T.","year":"2002","journal-title":"Circ. J."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja203007u"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","DOI":"10.3791\/52942","article-title":"Cardiac pressure\u2010volume loop analysis using conductance catheters in mice","author":"Abraham D.","year":"2015","journal-title":"J. Vis. Exp."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp118"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3253fje"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0975"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.7.1655"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.666941"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.02.004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.11.003"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.19.8671-8680.2004"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607215200"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0584"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-240168"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006-0146"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.04.005"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-06-0047"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.11.004"},{"key":"e_1_2_8_42_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00395-015-0495-4","article-title":"Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1","volume":"110","author":"Koentges C.","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"e_1_2_8_43_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/B978-0-12-801415-8.00012-6","article-title":"Measurement of ROS homeostasis in isolated mitochondria","volume":"547","author":"Tretter L.","year":"2014","journal-title":"Methods Enzymol."},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119416"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1034418"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.214700"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn017"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00086.2010"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.07.098"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01395.x"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201700505R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201700505R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201700505R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:07:13Z","timestamp":1761692833000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201700505R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,4]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1096\/fj.201700505R"],"URL":"https:\/\/doi.org\/10.1096\/fj.201700505r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,4]]},"assertion":[{"value":"2017-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}