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Although IPF is often associated with an imbalance in protease activity, the mechanisms underlying the sustained repair mechanisms are not fully understood. Here, we addressed the role of the recently identified, membrane\u2010anchored serine protease human airway trypsin\u2010like protease (HAT). In the present study, we show that both HAT expression and activity were up\u2010regulated in human IPF specimens. Next, adenoviral overexpression of HAT before bleomycin challenge attenuated lung injury as well as extracellular matrix deposition in the bleomycin\u2010induced pulmonary fibrosis model.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , HAT prevented specific fibrosis\u2010associated responses in primary human pulmonary fibroblasts and induced the expression of mediators associated with the prostaglandin E2 pathway. Altogether, our findings suggested that HAT could have a protective role in IPF and other fibrotic lung disorders.\u2014Menou, A., Flajolet, P., Duitmen, J., Justet, A., Moog, S., Jaillet, M., Tab\u00e8ze, L., Solhonne, B., Garnier, M., Mal, H., Mordant, P., Castier, Y., Cazes, A., Sallenave, J.\u2010M., Mailleux, A. A., Crestani, B. Human airway trypsin\u2010like protease exerts potent, anti\u2010fibrotic action in pulmonary fibrosis. FASEB J. 32, 1250\u20101264 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700583r","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T13:25:17Z","timestamp":1510233917000},"page":"1250-1264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Human airway trypsin\u2010like protease exerts potent, antifibrotic action in pulmonary fibrosis"],"prefix":"10.1096","volume":"32","author":[{"given":"Awen","family":"Menou","sequence":"first","affiliation":[{"name":"INSERM, Unit\u00e9 1552 Paris France"},{"name":"D\u00e9partement Hospitalo\u2010Universitaire Fibrosis, Inflammation, and Remodeling in Renal and Respiratory Diseases (FIRE) Paris France"},{"name":"Laboratoire d'Excellence Inflamex Paris 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