{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:34:33Z","timestamp":1790739273083,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004541","name":"Ministry of Human Resource Development","doi-asserted-by":"publisher","award":["MHR 02-23-200-429"],"award-info":[{"award-number":["MHR 02-23-200-429"]}],"id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fibulin\u20107 (Fbln7) has been identified as the latest member of the fibulin family of secreted glycoproteins in developing teeth, functioning as a cell adhesion molecule and interacting with other matrix proteins, receptors, and growth factors. More recently, we have shown that the C\u2010terminal Fbln7 fragment (Fbln7\u2010C) has antiangiogenic activity\n                    <jats:italic>in vitro.<\/jats:italic>\n                    Fbln7 is also expressed in immune\u2010privileged tissues, such as eye and placenta, but its functional significance is unknown. In the current study, we show that human monocytes adhere to both full\u2010length Fbln7 (Fbln7\u2010FL) and Fbln7\u2010C, in part,\n                    <jats:italic>via<\/jats:italic>\n                    integrins \u03b1\n                    <jats:sub>5<\/jats:sub>\n                    \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    and \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    . Morphologic studies and surface expression analyses of CD14, mannose receptor (CD206), major histocompatibility complex II, and CD11b receptors revealed that both Fbln7\u2010FL and Fbln7\u2010C inhibit M\u2010CSF\u2010induced monocyte differentiation. Fbln7\u2010C had significantly greater negative effects on cell spreading and stress fiber formation, including the production of IL\u20106 and metalloproteinase\u20101\/\u20109 compared with Fbln7\u2010FL. Furthermore, in an LPS\u2010induced systemic inflammation model, Fbln7\u2010C and Fbln7\u2010FL reduced the infiltration of immune cells, such as neutrophils and macrophages, to the inflamed peritoneum. Thus, these results suggest that Fbln7 and Fbln7\u2010C could modulate the activity of immune cells and have therapeutic potential for inflammatory diseases.\u2014Sarangi, P. P., Chakraborty, P., Dash, S. P., Ikeuchi, T., de Vega, S., Ambatipudi, K., Wahl, L., Yamada, Y. Cell adhesion protein fibulin\u20107 and its C\u2010terminal fragment negatively regulate monocyte and macrophage migration and functions\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . FASEB J. 32, 4889\u20134898 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700686rrr","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T14:40:57Z","timestamp":1523371257000},"page":"4889-4898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cell adhesion protein fibulin\u20107 and its C\u2010terminal fragment negatively regulate monocyte and macrophage migration and functions\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>"],"prefix":"10.1096","volume":"32","author":[{"given":"Pranita P.","family":"Sarangi","sequence":"first","affiliation":[{"name":"Molecular Biology Section Bethesda Maryland USA"},{"name":"Department of Biotechnology Indian Institute of Technology Roorkee Roorkee Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papiya","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Indian Institute of Technology Roorkee Roorkee Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiba Prasad","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Indian Institute of Technology Roorkee Roorkee Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Molecular Biology Section Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"de Vega","sequence":"additional","affiliation":[{"name":"Molecular Biology Section Bethesda Maryland USA"},{"name":"Research Institute for Diseases of Old Age Juntendo University School of Medicine Tokyo 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