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Podocytes share many morphologic features with neurons, so that similar sets of proteins appear to regulate cell process formation. One such protein is the tropomyosin\u2010related kinase C (TrkC). TrkC deficiency in mice leads to proteinuria as a surrogate of defective kidney filter function. Activation of endogenous TrkC by its ligand neurotrophin\u20103 resulted in increased podocyte migration\u2014a surrogate of podocyte actin dynamics\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Employing a mutagenesis approach, we found that the Src homologous and collagen\u2010like (Shc) binding site Tyr\n                    <jats:sup>516<\/jats:sup>\n                    within the TrkC cytoplasmic domain was necessary for TrkC\u2010induced migration of podocytes. TrkC activation led to a mobility shift of Wiskott\u2010Aldrich syndrome family verprolin\u2010homologous protein (WAVE)\u20102 which is known to orchestrate Arp2\/3 activation and actin polymerization. Chemical inactivation of Erk or mutagenesis of 2 of 4 known Erk target sites within WAVE2, Thr\n                    <jats:sup>346<\/jats:sup>\n                    and Ser\n                    <jats:sup>351<\/jats:sup>\n                    , abolished the TrkC\u2010induced WAVE2 mobility shift. Knockdown of WAVE2 by shRNA abolished TrkC\u2010induced podocyte migration. In sum\u2010mary, TrkC signals to the podocyte actin cytoskeleton to induce migration by phosphorylating WAVE2 Erk de\u2010pendently. This signaling mechanism may be important for TrkC\u2010mediated cytoskeletal dynamics in podocyte disease.\u2014Gromnitza, S., Lepa, C., Weide, T., Schwab, A., Pavenst \u00e4dt, H., George, B. Tropomyosin\u2010related kinase C (TrkC) enhances podocyte migration by ERK\u2010mediated WAVE2 activation. FASEB J. 32, 1665\u20101676 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700703r","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T13:10:27Z","timestamp":1511269827000},"page":"1665-1676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tropomyosin\u2010related kinase C (TrkC) enhances podocyte migration by ERK\u2010mediated WAVE2 activation"],"prefix":"10.1096","volume":"32","author":[{"given":"Sascha","family":"Gromnitza","sequence":"first","affiliation":[{"name":"Medizinische Klinik D Universit\u00e4tsklinikum M\u00fcnster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Lepa","sequence":"additional","affiliation":[{"name":"Medizinische Klinik D Universit\u00e4tsklinikum M\u00fcnster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Weide","sequence":"additional","affiliation":[{"name":"Medizinische Klinik D Universit\u00e4tsklinikum M\u00fcnster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Schwab","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physiologie II Westf\u00e4lische\u2010Wilhelms\u2010Universit\u00e4t M\u00fcnster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Pavenst\u00e4dt","sequence":"additional","affiliation":[{"name":"Medizinische Klinik D Universit\u00e4tsklinikum M\u00fcnster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"George","sequence":"additional","affiliation":[{"name":"Medizinische Klinik D Universit\u00e4tsklinikum M\u00fcnster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04662"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00948-07"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27414"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60070"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.556"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2012.06.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1681\/ASN.2009070691","article-title":"Signaling at the slit: podocytes chat by synaptic transmission","volume":"20","author":"Weide T.","year":"2009","journal-title":"J. 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