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Post\u2010translational modifications such as small ubiquitin\u2010like modifier (SUMO)ylation have emerged as critical molecular regulatory mechanisms in states of both homeostasis and ischemic stress, as evidenced by our previous work. Accordingly, the clinical significance of the selective control of the global SUMOylation process has become apparent in studies of ischemic pathobiology and pathophysiology. Herein, we describe a process capable of identifying and characterizing small molecules with the potential of targeting the SUMO system through inhibition of SUMO deconjugation in an effort to develop novel stroke therapies.\u2014Bernstock, J. D., Ye, D., Smith, J. A., Lee, Y.\u2010J., Gessler, F. A., Yasgar, A., Kouznetsova, J., Jadhav, A., Wang, Z., Pluchino, S., Zheng, W., Simeonov, A., Hallenbeck, J. M., Yang, W. Quantitative high\u2010throughput screening identifies cytoprotective molecules that enhance SUMO\u2010conjugation via the inhibition of SUMO\u2010specific protease (SENP)2. FASEB J. 32, 1677\u20101691 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700711r","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T16:15:35Z","timestamp":1510848935000},"page":"1677-1691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Quantitative high\u2010throughput screening identifies cytoprotective molecules that enhance SUMO conjugation\n                    <i>via<\/i>\n                    the inhibition of SUMO\u2010specific protease (SENP)2"],"prefix":"10.1096","volume":"32","author":[{"given":"Joshua D.","family":"Bernstock","sequence":"first","affiliation":[{"name":"Stroke Branch National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health Bethesda Maryland 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