{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:53:20Z","timestamp":1791204800641,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>\n                    Mice overexpressing galectin\u20108 [gal\u20108 transgenic (Tg)], a secreted mammalian lectin, exhibit enhanced bone turnover and reduced bone mass, similar to cases of postmenopausal osteoporosis. Here, we show that gal\u20108 knockout (KO) mice have increased bone mass accrual at a young age but exhibit accelerated bone loss during adulthood. These phenotypes can be attributed to a gal\u20108\u2010mediated increase in receptor activator of NF\u2010\u03baB ligand (RANKL) expression that promotes osteoclastogenesis, combined with direct inhibition of osteoblast differentiation, evident by reduced bone morphogenetic protein (BMP) signaling, reduced phosphorylation of receptor regulated mothers against decapentaplegic homolog (R\u2010SMAD) and reduced expression of osteoblast differentiation markers osterix, osteocalcin, runt\u2010related transcription factor 2 (RUNX2), dentin matrix acidic phosphoprotein\u20101 (DMP1), and alkaline phosphatase. At the same time, gal\u20108 promotes expression of estrogen receptor a (ESR1). Accordingly, the rate of bone loss is accelerated in ovariectomized, estrogen\u2010deficient gal\u20108 Tg mice, whereas gal\u20108 KO mice, having low levels of ESR1, are refractory to ovariectomy. Finally, gal\u20108 mRNA positively correlates with the mRNA levels of osteoclastogenic markers RANKL, tartrate\u2010resistant acid phosphatase, and cathepsin K in human femurs. Collectively, these findings identify gal\u20108 as a new physiologic player in the regulation of bone mass.\u2014Vinik, Y., Shatz\u2010Azoulay, H., Hiram\u2010Bab, S., Kandel, L., Gabet, Y., Rivkin, G., Zick, Y. Ablation of the mammalian lectin galectin\u20108 induces bone defects in mice. FASEB J. 32, 2366\u20132380 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700716r","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T10:53:21Z","timestamp":1513680801000},"page":"2366-2380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Ablation of the mammalian lectin galectin\u20108 induces bone defects in mice"],"prefix":"10.1096","volume":"32","author":[{"given":"Yaron","family":"Vinik","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology Weizmann Institute of Science Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadas","family":"Shatz\u2010Azoulay","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology Weizmann Institute of Science Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Hiram\u2010Bab","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Kandel","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankel","family":"Gabet","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurion","family":"Rivkin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehiel","family":"Zick","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology Weizmann Institute of Science Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8060376"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.01829.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2009.0282"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130203"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3254"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.2929"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp148"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2012.0014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1050-9_5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2013.02.011"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.179"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S112621"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi201121m"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2011.05.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.175"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-11-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05914"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32834bab18"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-010-9460-z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06479.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwu054"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7044-8"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10744"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27071"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01880415"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9153-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.9.3366"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00183-0"},{"key":"e_1_2_8_30_1","first-page":"19","article-title":"Osteoblast isolation from murine calvariae and long bones","volume":"80","author":"Bakker A.","year":"2003","journal-title":"Methods Mol. 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