{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:17:43Z","timestamp":1793917063037,"version":"4.8.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000971","name":"Diabetes Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>\n                    Inflammation is a critical phase in the healing of skin wounds. Excessive inflammation and inflammatory macrophages are known to cause impaired wound closure and outcome. This prompted us to test the role of IL\u201023 in IL\u201017 expression and in modulating wound inflammation and macrophage polarization. Full\u2010thickness wounds (4 \u00d7 6 mm) were created on the dorsal surface of multiple genetically modified mouse models. Obese diabetic mouse wounds were treated with anti\u2010IL\u201017A, anti\u2010IL\u201023, or isotype\u2010matched antibodies. We found IL\u201023\u2010 but not IL\u201012\u2010deficient mice displayed significantly reduced IL\u201017 expression in wounds. This was rescued by delivery of recombinant IL\u201023. IL\u201023\u2010 and IL\u201017\u2010deficient mice showed a significant increase in noninflammatory macrophages. Obese diabetic mice treated with anti\u2010IL\u201017A and anti\u2010IL\u201023p19 blocking antibodies had significantly improved wound reepithelialization. Similarly, IL\u201017\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    obese mice had accelerated wound closure, resulting in reduced iNOS expression and inflammatory macrophages while maintaining prohealing CD206 and lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1)\u2010expressing macrophages. This study highlights the importance of the IL\u201017 pathway in wound closure offering new possibilities of therapeutic intervention in chronic wounds.\u2014 Lee, J., Rodero, M. P., Patel, J., Moi, D., Mazzieri, R., Khosrotehrani, K. Interleukin\u201023 regulates interleukin\u201017 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    32, 2086\u20132094 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700773r","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T13:35:39Z","timestamp":1512480939000},"page":"2086-2094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Interleukin\u201023 regulates interleukin\u201017 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization"],"prefix":"10.1096","volume":"32","author":[{"given":"James","family":"Lee","sequence":"first","affiliation":[{"name":"University of Queensland Centre for Clinical Research and Translational Research Institute, Diamantina Institute, The University of Queensland Woolloongabba Queensland Australia"},{"name":"Translational Research Institute, Diamantina Institute, The University of Queensland Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu Paul","family":"Rodero","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research and Translational Research Institute, Diamantina Institute, The University of Queensland Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin","family":"Patel","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research and Translational Research Institute, Diamantina Institute, The University of Queensland Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Moi","sequence":"additional","affiliation":[{"name":"Translational Research Institute, Diamantina Institute, The University of Queensland Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Mazzieri","sequence":"additional","affiliation":[{"name":"Translational Research Institute, Diamantina Institute, The University of Queensland Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiarash","family":"Khosrotehrani","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research and Translational Research Institute, Diamantina Institute, The University of Queensland Woolloongabba Queensland Australia"},{"name":"Translational Research Institute, Diamantina Institute, The University of Queensland Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9381-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903356"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201301081"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-403386"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4548"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44490"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050293"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.09.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.081002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090248"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037084"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.368"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090048"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.01.001"},{"key":"e_1_2_8_16_1","first-page":"643","article-title":"Skin wound healing modulation by macrophages","volume":"3","author":"Rodero M. 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