{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:45:54Z","timestamp":1792665954592,"version":"4.5.0"},"reference-count":74,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>\n                    Transactive response DNA\u2010binding protein\u201043 (TDP\u201043) is involved in gene regulation\n                    <jats:italic>via<\/jats:italic>\n                    the control of RNA transcription, splicing, and transport. TDP\u201043 is a major protein component of ubiquinated inclusions that are found in amyotrophic lateral sclerosis (ALS); however, the function of TDP\u201043 at the neuromuscular junction (NMJ) and its role in ALS pathogenesis is largely unknown. Here, we show that TDP\u201043\n                    <jats:sup>Q331K<\/jats:sup>\n                    mutation in mice resulted in impaired neurotransmission by age 3 mo, preceding deficits in motor function and motor neuron loss, which were observed from age 10 mo. These defects were in the effective fusion and release of synaptic vesicles within the motor nerve terminal and manifested in decreased quantal content and reduced probability of quantal release. We observed morphologic alterations that were associated with the TDP\u201043\n                    <jats:sup>Q331K<\/jats:sup>\n                    mutation, such as aberrant innervation patterns and the distribution of synaptic vesicle\u2010related proteins, which is indicative of a failing NMJ undergoing synaptic remodeling. These findings support a growing acceptance that dysregulation of the NMJ function is a key early event in the pathology of ALS.\u2014Chand, K. K., Lee, K. M., Lee, J. D, Qiu, H., Willis, E. F., Lavidis, N. A., Hilliard, M. A., Noakes, P. G. Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP\u201043Q331K transgenic mouse model of amyotrophic lateral sclerosis. FASEB J. 32, 2676\u20132689 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700835r","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T16:31:44Z","timestamp":1514910704000},"page":"2676-2689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP\u201043\n                    <sup>Q331K<\/sup>\n                    transgenic mouse model of amyotrophic lateral sclerosis"],"prefix":"10.1096","volume":"32","author":[{"given":"Kirat K.","family":"Chand","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah 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