{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:37:52Z","timestamp":1792985872185,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>\n                    The functions of the paralogous transcriptional coactivators Yes\u2010associated protein (YAP) and transcriptional coactivator with PDZ\u2010binding motif (TAZ) in bone are controversial. Each has been observed to promote or inhibit osteogenesis\n                    <jats:italic>in vitro<\/jats:italic>\n                    , with reports of both equivalent and divergent functions. Their combinatorial roles in bone physiology are unknown. We report that combinatorial YAP\/TAZ deletion from skeletal lineage cells, using Osterix\u2010Cre, caused an osteogenesis imperfecta\u2010like phenotype with severity dependent on allele dose and greater phenotypic expressivity with homozygous TAZ\n                    <jats:italic>vs.<\/jats:italic>\n                    YAP ablation. YAP\/TAZ deletion decreased bone accrual and reduced intrinsic bone material properties through impaired collagen content and organization. These structural and material defects produced spontaneous fractures, particularly in mice with homozygous TAZ deletion and caused neonatal lethality in dual homozygous knockouts. At the cellular level\n                    <jats:italic>in vivo<\/jats:italic>\n                    , YAP\/TAZ ablation reduced osteoblast activity and increased osteoclast activity, in an allele dose\u2010dependent manner, impairing bone accrual and remodeling. Transcriptionally, YAP\/TAZ deletion and small\u2010molecule inhibition of YAP\/TAZ interaction with the transcriptional coeff ector TEAD reduced osteogenic and collagen\u2010related gene expression, both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro.<\/jats:italic>\n                    These data demonstrate that YAP and TAZ combinatorially promote bone development through regulation of osteoblast activity, matrix quality, and osteoclastic remodeling.\u2014Kegelman, C. D., Mason, D. E., Dawahare, J. H., Horan, D. J., Vigil, G. D., Howard, S. S., Robling, A. G., Bellido, T. M., Boerckel, J. D. Skeletal cell YAP and TAZ combinatorially promote bone development. FASEB J. 32, 2706\u20132721 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700872r","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T14:33:21Z","timestamp":1516890801000},"page":"2706-2721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["Skeletal cell YAP and TAZ combinatorially promote bone development"],"prefix":"10.1096","volume":"32","author":[{"given":"Christopher D.","family":"Kegelman","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon E.","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of 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