{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:30:49Z","timestamp":1784334649819,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2017YFA0104900"],"award-info":[{"award-number":["2017YFA0104900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>\n                    Bone marrow\u2010derived mesenchymal stem cell (BMSC) cytotherapy has emerged as a promising treatment strategy for refractory immune diseases; however, the influence of the pathologic conditions of donors on the immunomodulatory properties of BMSCs is still poorly understand. Here, we found that BMSCs that were derived from donors with osteoporosis were ineffective as cytotherapy for patients with experimental colitis and graft\u2010vs.\u2010host disease (GVHD).\n                    <jats:italic>In vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    assays revealed that the capacity of osteoporotic BMSCs to induce T\u2010cell apoptosis declined as a result of decreased Fas and FasL protein. Additional analysis revealed that let\u20107a, a micro\u2010RNA induced by TNF\u2010\u03b1 in osteoporosis, inhibited the expression of the Fas\/FasL system\n                    <jats:italic>via<\/jats:italic>\n                    post\u2010transcriptional regulation. By knocking down let\u20107a expression, we successfully recovered the immunosuppressive capacity of osteoporotic BMSCs and improved their therapy for experimental colitis and GVHD. Taken together, our study demonstrates that the immunomodulatory properties of BMSCs are suppressed in osteoporosis and illustrates the molecular mechanism that underlies this suppression. These findings might have important implications for the development of targeted strategies to improve BMSC cytotherapy.\u2014 Liao, L., Yu, Y., Shao, B., Su, X., Wang, H., Kuang, H., Jing, H., Shuai, Y., Yang, D., Jin, Y. Redundant let\u20107a suppresses the immunomodulatory properties of BMSCs by inhibiting the Fas\/FasL system in osteoporosis.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    32, 1982\u20131992 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700885r","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T11:00:14Z","timestamp":1512385214000},"page":"1982-1992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Redundant let\u20107a suppresses the immunomodulatory properties of BMSCs by inhibiting the Fas\/FasL system in osteoporosis"],"prefix":"10.1096","volume":"32","author":[{"given":"Li","family":"Liao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Military 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