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We report that matrix metalloproteinase 14 (MMP14) expression\/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor 1 (PTH1R) in Ots (caPTH1R\n                    <jats:sup>Ot<\/jats:sup>\n                    ) and in bones from mice exposed to elevated PTH levels but not in mice lacking [conditional knockout (cKO)] the PTH1R in Ots (cKOPTH1R\n                    <jats:sup>Ot<\/jats:sup>\n                    ). Furthermore, PTH upregulates\n                    <jats:italic>MMP<\/jats:italic>\n                    14 in human bone cultures and in Ot\u2010enriched bones from floxed control mice but not from cKOPTH1R\n                    <jats:sup>Ot<\/jats:sup>\n                    mice. MMP14 activity increases soluble receptor activator of NF\u2010\u03baB ligand production, which in turn, stimulates osteoclast differentiation and resorption. Pharmacologic inhibition of MMP14 activity reduced the high bone remodeling exhibited by caPTH1R\n                    <jats:sup>Ot<\/jats:sup>\n                    mice or induced by chronic PTH elevation and decreased bone resorption but allowed full stimulation of bone formation induced by PTH injections, thereby potentiating bone gain. Thus, MMP14 is a new member of the intricate gene network activated in Ots by PTH1R signaling that can be targeted to adjust the skeletal responses to PTH in favor of bone preservation.\u2014Delgado\u2010Calle, J., Hancock, B., Likine, E. F., Sato, A. Y., McAndrews, K., Sanudo, C., Bruzzaniti, A., Riancho, J. A., Tonra, J. R., Bellido, T. MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production. FASEB J. 32, 2878\u20132890 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700919rrr","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T08:01:56Z","timestamp":1516176116000},"page":"2878-2890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production"],"prefix":"10.1096","volume":"32","author":[{"given":"Jesus","family":"Delgado\u2010Calle","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Indiana University School of Medicine Indianapolis Indiana USA"},{"name":"Division of Endocrinology Department of Medicine Indiana University School of Medicine Indianapolis Indiana USA"},{"name":"Department of Anatomy and Cell Biology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Hancock","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elive F.","family":"Likine","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Y.","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"McAndrews","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Sanudo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Marque\u00b4s de Valdecilla University Hospital\u2013Instituto de Investigacio\u00b4n Marque\u00b4s de Valdecilla (IDIVAL) University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Bruzzaniti","sequence":"additional","affiliation":[{"name":"Indiana Center for Musculoskeletal Health Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Riancho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Marque\u00b4s de Valdecilla University Hospital\u2013Instituto de Investigacio\u00b4n Marque\u00b4s de Valdecilla (IDIVAL) University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Tonra","sequence":"additional","affiliation":[{"name":"Kadmon Corporation New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresita","family":"Bellido","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Medicine Indiana University School of Medicine Indianapolis Indiana USA"},{"name":"Department of Anatomy and Cell Biology Indiana University School of Medicine Indianapolis Indiana USA"},{"name":"Indiana Center for Musculoskeletal Health Indianapolis Indiana USA"},{"name":"Richard L. 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