{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:44:05Z","timestamp":1782456245519,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011512","name":"National Science Foundation, United Arab Emirates","doi-asserted-by":"publisher","award":["2014M3C9A2067613"],"award-info":[{"award-number":["2014M3C9A2067613"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Science Foundation, United Arab Emirates","doi-asserted-by":"publisher","award":["2015M3A9B6027555"],"award-info":[{"award-number":["2015M3A9B6027555"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2017R1C1B2002806"],"award-info":[{"award-number":["2017R1C1B2002806"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited disorders. ADPKD is caused by mutations in the gene encoding either polycystic kidney disease 1\n                    <jats:italic>(PKD1)<\/jats:italic>\n                    or polycystic kidney disease 2 (PKD2). Patients with ADPKD show progressive growth of cystic fluid\u2010filled renal cysts. Here, we used\n                    <jats:italic>\n                      Pkd2\n                      <jats:sup>f\/f<\/jats:sup>\n                    <\/jats:italic>\n                    control mice and\n                    <jats:italic>\n                      Pkd2\n                      <jats:sup>f\/f<\/jats:sup>\n                      :HoxB7\u2010Cre\n                    <\/jats:italic>\n                    experimental mice, which are bred to have a conditional deletion of\n                    <jats:italic>Pkd2<\/jats:italic>\n                    in the collecting ducts, and analyzed the expression pattern of microRNAs (miRNAs) of kidney tissues from\n                    <jats:italic>\n                      Pkd2\n                      <jats:sup>f\/f<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      Pkd2\n                      <jats:sup>f\/f<\/jats:sup>\n                      :HoxB7\u2010Cre\n                    <\/jats:italic>\n                    mice. Decreased expression of miR\u201020b\u20105p and miR\u2010106a\u20105p in\n                    <jats:italic>\n                      Pkd2\n                      <jats:sup>f\/f<\/jats:sup>\n                      :HoxB7\u2010Cre\n                    <\/jats:italic>\n                    mice compared to that in\n                    <jats:italic>\n                      Pkd2\n                      <jats:sup>f\/f<\/jats:sup>\n                    <\/jats:italic>\n                    mice was observed. These miRNAs target\n                    <jats:italic>Klf12<\/jats:italic>\n                    (Kriippel\u2010like factor 12), which has low expression in kidney tissues of\n                    <jats:italic>\n                      Pkd2\n                      <jats:sup>f\/f<\/jats:sup>\n                    <\/jats:italic>\n                    mice; however, its expression is enhanced in\n                    <jats:italic>\n                      Pkd2\n                      <jats:sup>f\/f<\/jats:sup>\n                      :HoxB7\u2010Cre\n                    <\/jats:italic>\n                    mice over time. Moreover, miR\u201020b\u20105p and miR\u2010106a\u20105p directly target\n                    <jats:italic>Klf12<\/jats:italic>\n                    mRNA by binding to the 3\u2032\u2010UTR of\n                    <jats:italic>Klf12.ln<\/jats:italic>\n                    addition, human and mouse cell lines exhibit similar patterns. These findings were also consistent with the data from\n                    <jats:italic>Pkd2<\/jats:italic>\n                    knockout mouse embryonic fibroblasts. Furthermore, direct and indirect knockdown of\n                    <jats:italic>Klf12<\/jats:italic>\n                    slows cyst growth and cell proliferation in mouse inner medullary collecting duct cells. Taken together, we suggest that the induction of miR\u201020b\u20105p or miR\u2010106a\u20105p or the down\u2010regulation of KLF12 could be used as potential novel therapies for inhibiting cyst growth in patients with ADPKD.\u2014Shin, Y., Kim, D.Y., Ko, J.Y., Woo, Y. M., Park, J. H. Regulation of KLF12 by microRNA\u201020b and microRNA\u2010106a in cystogenesis. FASEB J. 32, 3574\u20133582 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700923r","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T14:41:44Z","timestamp":1518792104000},"page":"3574-3582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Regulation of KLF12 by microRNA\u201020b and microRNA\u2010106a in cystogenesis"],"prefix":"10.1096","volume":"32","author":[{"given":"Yubin","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Sookmyung Women's University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Sookmyung Women's University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je Yeong","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Sookmyung Women's University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Mi","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Sookmyung Women's University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Sookmyung Women's University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.152"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.59"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.128"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.11.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72272"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.01.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.448"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2632"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00058.2009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.1.194"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24538"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3582"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.03.138"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"14151","DOI":"10.1038\/s41598-017-14083-8","article-title":"Profiling of miRNAs and target genes related to cystogenesis in ADPKD mouse models","volume":"7","author":"Woo Y. M.","year":"2017","journal-title":"Sci. Rep."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-13-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01228-12"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201700923R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201700923R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201700923R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:20:31Z","timestamp":1761693631000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201700923R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,16]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1096\/fj.201700923R"],"URL":"https:\/\/doi.org\/10.1096\/fj.201700923r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,16]]},"assertion":[{"value":"2017-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}