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The current study investigated the potential effect of ginsenoside Rh2 (GRh2) on neovascularization. In HUVECs, pretreatment with GRh2 largely attenuated VEGF\u2010induced cell proliferation, migration, and vessel\u2010like tube formation\n                    <jats:italic>in vitro.<\/jats:italic>\n                    At the molecular level, GRh2 disrupted VEGF\u2010induced VEGF receptor 2(VEGFR2)\u2010Grb\u20102\u2010associated binder 1 (Gab1) association in HUVECs, causing inactivation of downstream AKT and ERK signaling. Gab1 knockdown (by targeted short hairpin RN\n                    <jats:italic>A<\/jats:italic>\n                    ) similarly inhibited HUVEC proliferation and migration. Notably, GRh2 was ineffective against VEGF in Gab1\u2010silenced HUVECs. In a mouse cornea alkali burn model, GRh2 eyedrops inhibited alkali\u2010induced neovascularization and inflammatory cell infiltrations in the cornea. Furthermore, alkali\u2010induced corneal expression of\n                    <jats:italic>mRNAs\/long<\/jats:italic>\n                    noncoding RNAs in cornea were largely attenuated by GRh2. Overall, GRh2 inhibits VEGF\u2010induced an\u2010giogenic effect\n                    <jats:italic>via<\/jats:italic>\n                    inhibiting VEGFR2\u2010Gab1 signaling in\n                    <jats:italic>vitro.<\/jats:italic>\n                    It also alleviates angiogenic and inflammatory responses in alkali burn\u2010treated mouse corneas.\u2014Zhang, X.\u2010P., Li, K.\u2010R., Yu, Q., Yao, M.\u2010D., Ge, H.\u2010M., Li, X.\u2010M., Jiang, Q., Yao, J., Cao, C. Ginsenoside Rh2 inhibits vascular endothelial growth factor\u2010induced corneal neovascularization. FASEB J. 32, 3782\u20133791 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201701074rr","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T16:31:56Z","timestamp":1519144316000},"page":"3782-3791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Ginsenoside Rh2 inhibits vascular endothelial growth factor\u2010induced corneal neovascularization"],"prefix":"10.1096","volume":"32","author":[{"given":"Xiao\u2010Pei","family":"Zhang","sequence":"first","affiliation":[{"name":"The Fourth School of Clinical Medicine The Affiliated Eye Hospital Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke\u2010Ran","family":"Li","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine The Affiliated Eye Hospital Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yu","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine The Affiliated Eye Hospital Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu\u2010Di","family":"Yao","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine The Affiliated Eye Hospital Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Min","family":"Ge","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine The Affiliated Eye Hospital Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010Miao","family":"Li","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine The Affiliated Eye Hospital Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine The Affiliated Eye Hospital Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Yao","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine The Affiliated Eye Hospital Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Cao","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine The Affiliated Eye Hospital Nanjing Medical University Nanjing China"},{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases Research and Institute of Neuroscience Soochow University Suzhou China"},{"name":"North District The Municipal Hospital of Suzhou Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"182","article-title":"Clinical correlates of common corneal neovascular diseases: a literature review","volume":"8","author":"Abdelfattah N. 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