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However, fundamental knowledge underpinning how cancer cells reprogram mitochondrial morphogenesis remains incomplete. Here, we report that cystathionine \u03b2\u2010synthase (CBS) reprograms mitochondrial morphogenesis in ovarian cancer (OvCa) cells by selectively regulating the stability of mitofusin 2 (MFN2). Clinically, high expression of both\n                    <jats:italic>CBS<\/jats:italic>\n                    and\n                    <jats:italic>MFN2<\/jats:italic>\n                    implicates poor overall survival of OvCa patients, and a significant association between CBS and\n                    <jats:italic>MFN2<\/jats:italic>\n                    expression exists in individual patients in the same data set. The silencing of CBS by small interfering RNA or inhibition of its catalytic activity by a small molecule inhibitor creates oxidative stress that activates JNK. Activated JNK phosphorylates MFN2 to recruit homologous to the E6\u2010AP carboxyl terminus' domain\u2010containing ubiquitin E3 ligase for its degradation\n                    <jats:italic>via<\/jats:italic>\n                    the ubiquitin\u2010proteasome system. Supplementation with hydrogen sulfide or glutathione (the catalytic products of CBS enzymatic activity), anti\u2010oxidants, or a JNK inhibitor restores MFN2 expression. In CBS\u2010silenced orthotopic xenograft tumor tissues, MFN2 but not MFN1 is selectively downregulated. In summary, this report reveals a role for deregulated mitochondrial morphogenesis in OvCa, suggests one of the mechanisms for this deregulation, and provides a way to correct it through modulation of the metabolic enzyme CBS.\u2014Chakraborty, P. K., Murphy, B., Mustafi, S. B., Dey, A., Xiong, X., Rao, G., Naz, S., Zhang, M., Yang, D., Dhanasekaran, D. N., Bhattacharya, R., Mukherjee P. Cystathionine b\u2010synthase regulates mito\u2010chondrial morphogenesis in ovarian cancer.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 32, 4145\u20134157 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201701095r","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T17:02:44Z","timestamp":1519923764000},"page":"4145-4157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Cystathionine \u03b2\u2010synthase regulates mitochondrial morphogenesis in ovarian cancer"],"prefix":"10.1096","volume":"32","author":[{"given":"Prabir","family":"Kumar Chakraborty","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Oklahoma Health Sciences Center Oklahoma City 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