{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:50:58Z","timestamp":1790063458593,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T00:00:00Z","timestamp":1522281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["12 BSV1 0032-01"],"award-info":[{"award-number":["12 BSV1 0032-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Prolactin (PRL), whose principal role is regulation of lactation, is mainly synthesized and secreted by lactotroph anterior pituitary cells. Its signaling is exerted\n                    <jats:italic>via<\/jats:italic>\n                    a transmembrane PRL receptor (PRLR) expressed in a wide variety of tissues, including the anterior pituitary. Dopamine, which is secreted by tuberoinfundibular hypothalamic neurons, is the major inhibitory regulator of prolactin secretion. Although PRL is well established to stimulate hypothalamic dopamine secretion, thereby exerting a negative feedback regulation on its own release, autocrine or paracrine actions of PRL on lactotroph cells have also been suggested. Within the pituitary, PRL may inhibit both lactotroph proliferation and secretion, but\n                    <jats:italic>in vivo<\/jats:italic>\n                    evaluation of these putative functions is limited. To determine whether the autocrine actions of prolactin have a significant role in the physiologic function of lactotrophs in vivo, we examined the consequences of conditional deletion of\n                    <jats:italic>Prlr<\/jats:italic>\n                    in lactotroph cells using a novel mouse line with loxP sites flanking the\n                    <jats:italic>Prlr<\/jats:italic>\n                    gene (\n                    <jats:italic>Prlr<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>loxl\/lox<\/jats:italic>\n                    <\/jats:sup>\n                    ) and Cre\u2010recombinase (Cre) expressed under the control of the pituitary\u2010specific Prl promoter. Prlr\n                    <jats:sup>\n                      <jats:italic>lox\/lox<\/jats:italic>\n                    <\/jats:sup>\n                    \/Prl\u2010Cre mice have normal PRL levels and did not develop any pituitary lactotroph adenoma, even at 20 mo of age. Nevertheless,\n                    <jats:italic>Prlr<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>loxl\/lox<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>lPrl\u2010Cre<\/jats:italic>\n                    mice displayed an increased dopaminergic inhibitory tone compared with control\n                    <jats:italic>Prlr<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>lox\/lox<\/jats:italic>\n                    <\/jats:sup>\n                    mice. These results elegantly confirm an autocrine\/paracrine feedback of PRL on lactotroph cells\n                    <jats:italic>in vivo<\/jats:italic>\n                    , which can be fully compensated by an intact hypothalamic feedback system.\u2014Bernard, V., Lamothe, S., Beau, I., Guillou, A., Martin, A., Le Tissier, P., Grattan, D., Young, J., Binart, N. Autocrine actions of prolactin contribute to the regulation of lactotroph function\n                    <jats:italic>in vivo<\/jats:italic>\n                    . FASEBJ. 32, 4791\u20134797 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201701111rr","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T14:38:24Z","timestamp":1522334304000},"page":"4791-4797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Autocrine actions of prolactin contribute to the regulation of lactotroph function\n                    <i>in vivo<\/i>"],"prefix":"10.1096","volume":"32","author":[{"given":"Valerie","family":"Bernard","sequence":"first","affiliation":[{"name":"Unit\u00e9 INSERM 1185 Facult\u00e9 de M\u00e9decine Paris Sud Universit\u00e9 Paris-Saclay Le Kremlin-Bicetre 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