{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:06:46Z","timestamp":1787238406276,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AT006704"],"award-info":[{"award-number":["AT006704"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL132989"],"award-info":[{"award-number":["HL132989"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P01\u2010GM095467"],"award-info":[{"award-number":["P01\u2010GM095467"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM038765\u201032"],"award-info":[{"award-number":["GM038765\u201032"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    Resolvins are innate, immune responsive, bioactive mediators generated after myocardial infarction (MI) to resolve inflammation. The MI\u2010induced bidirectional interaction between progressive left ventricle (LV) remodeling and kidney dysfunction is known to advance cardiorenal syndrome (CRS). Whether resolvins limit MI\u2010induced cardiorenal inflammation is unclear. Thus, to define the role of exogenous resolvin D (RvD)\u20101 in post\u2010MI CRS, we subjected 8\u2010 to 12\u2010wk\u2010old male C57BL\/6 mice to coronary artery ligation. RvD1 was injected 3 h after MI. MI mice with no treatment served as MI controls (d 1 and 5). Mice with no surgery served as naive controls. In the injected mice, RvD1 promoted neutrophil (CD11b\n                    <jats:sup>+<\/jats:sup>\n                    \/Ly6G\n                    <jats:sup>+<\/jats:sup>\n                    ) egress from the infarcted LV, compared with the MI control group at d 5, indicative of neutrophil clearance and thereby resolved inflammation. Further, RvD1\u2010injected mice showed higher reparative macrophages (F4\/80+\/Ly6C\n                    <jats:sup>low<\/jats:sup>\n                    \/CD206\n                    <jats:sup>+<\/jats:sup>\n                    ) in the infarcted LV than did MI control mice at d 5 after MI. RvD1 suppressed the miRNA storm at d 1 and limited the MI\u2010induced edematous milieu in a remote area of the LV compared with the MI control at d 5 after MI. Also, RvD1 preserved the nephrin expression that was diffuse in the glomerular membrane at d 5 and 28 in MI controls, indicating renal injury. RvD1 attenuated MI\u2010induced renal inflammation, decreasing neutrophil gelatinase\u2010associated lipocalin and proinflammatory cytokines and chemokines in the kidney compared with the MI control. In summary, RvD1 clears MI\u2010induced inflammation by increasing resolving leukocytes and facilitates renoprotective mechanisms to limit CRS in acute and chronic heart failure.\u2014Halade, G.V., Kain, V., Serhan, C.N. Immune responsive resolvin D1 programsmyocardial infarction\u2010induced cardiorenal syndrome in heart failure. FASEB J. 32, 3717\u20133729 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201701173rr","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T15:10:55Z","timestamp":1518534655000},"page":"3717-3729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Immune responsive resolvin D1 programs myocardial infarction\u2010induced cardiorenal syndrome in heart failure"],"prefix":"10.1096","volume":"32","author":[{"given":"Ganesh V.","family":"Halade","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Disease Department of Medicine The University of Alabama at Birmingham Birmingham Alabama 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