{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:57:30Z","timestamp":1789999050557,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T00:00:00Z","timestamp":1522713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503176"],"award-info":[{"award-number":["81503176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vitiligo is a depigmentary disorder that develops as a result of the progressive disappearance of epidermal melanocytes. Stress can precipitate or exacerbate a skin disease through psychosomatic mechanisms. Stress exposure induces vitiligo\u2010like symptoms in mice, as cellular damage to melanocytes causes synthetic pigment loss. Stress also increases IL\u201017, IL\u20101\u03b2, and antimelanocyte IgG in model mouse serum. Up\u2010regulation of the IL\u20101\u03b2 transcript in patients suggests its possible role in autoimmune pathogenesis of vitiligo. We demonstrate that IL\u201017 promoted IL\u20101\u03b2 secretion from keratinocytes. Mitochondrial dysfunction, which can induce the excessive production of reactive oxygen species (ROS), is emerging as a mechanism that underlies various inflammatory and autoimmune diseases. In this study, we demonstrate that IL\u201017 inhibits melanogenesis of zebrafish, normal human epidermal melanocytes, and B16F10 cells. IL\u201017 increased mitochondrial dysfunc\u2010tion and ROS accumulation, which was related to autophagy induction. Autophagy is needed for autophagic apoptosis of B16F10 cells induced by IL\u201017. To inhibit ROS generation, B16F10 cells were pretreated with\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010L\u2010cysteine (NAC), which inhibited autophagy. 3\u2010Methyladenine (3\u2010MA) also had an inhibiting effect on autophagy. NAC or 3\u2010MA pretreatments inhibited IL\u201017\u2010mediated cell apoptosis. In summary, IL\u201017 induces the cellular stress microenvironment in melanocytes to promote autophagic cell apoptosis in vitiligo.\u2014Zhou, J., An, X., Dong, J., Wang, Y., Zhong, H., Duan, L., Ling, J., Ping, F., Shang, J. IL\u201017 induces cellular stress microenvironment of melanocytes to promote autophagic cell apoptosis in vitiligo. FASEB J. 32, 4899\u20134916 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201701242rr","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T13:53:57Z","timestamp":1522763637000},"page":"4899-4916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["IL\u201017 induces cellular stress microenvironment of melanocytes to promote autophagic cell apoptosis in vitiligo"],"prefix":"10.1096","volume":"32","author":[{"given":"Jia","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Translational Research China Pharmaceutical University Nanjing China"},{"name":"Jiangsu Key Laboratory of Traditional Chinese Medicine (TCM) Evaluation and Translational Research China Pharmaceutical 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