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Signaling between retinal neurons is regulatedby the release and uptake of neurotransmitters, wherein GABA is the main inhibitory neurotransmitter. In this work, novel 3\u2010chloropropiophenone derivatives and the clinical anticonvulsants tiagabine and vigabatrin were tested to modulate GABA signaling and protect against light\u2010induced retinal degeneration.\n                    <jats:italic>Abca4<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <jats:italic>Rdh8<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, an accelerated model of retinal degeneration, were exposed to intense light after prophylactic injections of one of these compounds. Imaging and functional assessments of the retina indicated that these compounds successfully protected photoreceptor cells from degeneration to maintain a full\u2010visual\u2010field response. Furthermore, these compounds demonstrated a strong safety profile in wild\u2010type mice and did not compromise visual function or damage the retina, despite repeated administration. These results indicate that modulating inhibitory GABA signaling can offer prophylactic protection against light\u2010induced retinal degeneration.\u2014Schur, R. M., Gao, S., Yu, G., Chen, Y., Maeda, A., Palczewski, K., Lu, Z.\u2010R. New GABA modulators protect photoreceptor cells from light\u2010induced degeneration in mouse models. FASEB J. 32, 3289\u20133300 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201701250r","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T09:54:12Z","timestamp":1516787652000},"page":"3289-3300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["New GABA modulators protect photoreceptor cells from light\u2010induced degeneration in mouse models"],"prefix":"10.1096","volume":"32","author":[{"given":"Rebecca M.","family":"Schur","sequence":"first","affiliation":[{"name":"Case Center for Biomolecular Engineering Department of Biomedical Engineering School of Engineering, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songqi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cleveland Center for Membrane and Structural Biology School of Medicine, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanping","family":"Yu","sequence":"additional","affiliation":[{"name":"Case Center for Biomolecular Engineering Department of Biomedical Engineering School of Engineering, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cleveland Center for Membrane and Structural Biology School of Medicine, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences School of Medicine, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Palczewski","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cleveland Center for Membrane and Structural Biology School of Medicine, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Rong","family":"Lu","sequence":"additional","affiliation":[{"name":"Case Center for Biomolecular Engineering Department of Biomedical Engineering School of Engineering, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090413-025610"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804505200"},{"key":"e_1_2_8_4_1","first-page":"32","article-title":"Oxidative damage and age-related macular degeneration","volume":"5","author":"Winkler B. 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