{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:20:04Z","timestamp":1790202004608,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Regulatory T (T\n                    <jats:sub>reg<\/jats:sub>\n                    ) cells offer new therapeutic options for controlling undesired systemic and local immune responses. The aim of the current study was to determine the impact of therapeutic T\n                    <jats:sub>reg<\/jats:sub>\n                    administration on systemic and cardiac inflammation and remodeling in coxsackievirus B3 (CVB3) \u2010induced myocarditis. Therefore, syngeneic T\n                    <jats:sub>reg<\/jats:sub>\n                    cells were applied intravenously in CVB3\u2010infected mice 3 d after infection. Compared with CVB3 + PBS mice, CVB3 + T\n                    <jats:sub>reg<\/jats:sub>\n                    mice exhibited lower left ventricle (LV) chemokine expression, accompanied by reduced cardiac presence of proinflammatory Ly6C\n                    <jats:sup>high<\/jats:sup>\n                    CCR2\n                    <jats:sup>high<\/jats:sup>\n                    Cx3Cr1\n                    <jats:sup>low<\/jats:sup>\n                    monocytes and higher retention of proin flammatory Ly6C\n                    <jats:sup>mid<\/jats:sup>\n                    CCR2\n                    <jats:sup>high<\/jats:sup>\n                    Cx3Cr1\n                    <jats:sup>low<\/jats:sup>\n                    monocytes in the spleen. In addition, splenic myelopoiesis was reduced in CVB3 + Treg compared with CVB3 + PBS mice. Coculture of Treg cells with splenocytes isolated from mice 3 d post\u2010 CVB3 infection further demonstrated the ability of T\n                    <jats:sub>reg<\/jats:sub>\n                    cells to modulate monocyte differentiation in favor of the anti\u2010inflammatory Ly6C\n                    <jats:sup>low<\/jats:sup>\n                    CCR2\n                    <jats:sup>low<\/jats:sup>\n                    Cx3Cr1\n                    <jats:sup>high<\/jats:sup>\n                    subset. T\n                    <jats:sub>reg<\/jats:sub>\n                    \u2010mediated immunomodulation was paralleled by lower collagen 1 protein expression and decreased levels of soluble and insoluble collagen in LV of CVB3 + T\n                    <jats:sub>reg<\/jats:sub>\n                    compared with CVB3 + PBS mice. In agreement with these findings, LV systolic and diastolic function was improved in CVB3 + T\n                    <jats:sub>reg<\/jats:sub>\n                    mice compared with CVB3 + PBS mice. In summary, adoptive T\n                    <jats:sub>reg<\/jats:sub>\n                    transfer in the inflammatory phase of viral\u2010induced myocarditis protects the heart against inflammatory damage and fibrosis\n                    <jats:italic>via<\/jats:italic>\n                    modulation of monocyte subsets.\u2014Pappritz, K., Savvatis, K., Miteva, K., Kerim, B., Dong, F., Fechner, H., M\u00fcller, I., Brandt, C., Lopez, B., Gonz\u00e1lez, A., Ravassa, S., Klingel, K., Diez, J., Reinke, P., Volk, H.\u2010D., Van Linthout, S., Tsch\u00f6pe, C. Immunomod ulation by adoptive regulatory T\u2010cell transfer improves Coxsackievirus B3\u2010induced myocarditis.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 32, 6066\u20136078 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201701408r","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T14:28:25Z","timestamp":1528122505000},"page":"6066-6078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Immunomodulation by adoptive regulatory T\u2010cell transfer improves Coxsackievirus B3\u2010induced myocarditis"],"prefix":"10.1096","volume":"32","author":[{"given":"Kathleen","family":"Pappritz","sequence":"first","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies University Medicine Berlin Berlin Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Berlin Germany"},{"name":"Institute for Pathology and Neuropathology University Hospital Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Savvatis","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies University Medicine Berlin Berlin Germany"},{"name":"Inherited Cardiovascular Diseases Unit, Barts Heart Centre Barts Health National Health Service (NHS) Trust London United Kingdom"},{"name":"William Harvey Research Institute, Queen Mary University London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapka","family":"Miteva","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies University Medicine Berlin Berlin Germany"},{"name":"Adaptive Immunity Laboratory, Humanitas Clinical and Research Center, Department of Biomedical Sciences Humanitas University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahtiyar","family":"Kerim","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies University Medicine Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengquan","family":"Dong","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies University Medicine Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Fechner","sequence":"additional","affiliation":[{"name":"Department of Applied Biochemistry, Institute for Biotechnology Technische Universit\u00e4t Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies University Medicine Berlin Berlin Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Berlin Germany"},{"name":"Institute for Pathology and Neuropathology University Hospital Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Brandt","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies University Medicine Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u0144a","family":"Lopez","sequence":"additional","affiliation":[{"name":"Centre for Applied Medical Research (CIMA), Department of Cardiology and Cardiac Surgery University of Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Centre for Applied Medical Research (CIMA), Department of Cardiology and Cardiac Surgery University of Navarra 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Reinke","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies University Medicine Berlin Berlin Germany"},{"name":"Department of Nephrology and Intensive Medicine University Medicine Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Dieter","family":"Volk","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies University Medicine Berlin Berlin Germany"},{"name":"Institute of Medical Immunology, Campus Virchow Klinikum, Charit\u00e9 University Medicine Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Van Linthout","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies University Medicine Berlin Berlin Germany"},{"name":"Department of Cardiology University Medicine 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