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However, the effect of\n                    <jats:italic>Seipin<\/jats:italic>\n                    on renal function is poorly understood. Here we report that\n                    <jats:italic>Seipin<\/jats:italic>\n                    knockout (SKO) mice exhibited impaired renal function, enlarged glomerular and mesangial surface areas, renal depositions of lipid, and advanced glycation end products. Elevated glycosuria and increased electrolyte excretion were also detected. Relative renal gene expression in fatty acid oxidation and reabsorption pathways were impaired in SKO mice. Elevated glycosuria might be associated with reduced renal glucose transporter 2 levels. To improve renal function, AT transplantation or leptin administration alone was performed. Both treatments effectively ameliorated renal injury by improving all of the parameters that were measured in the kidney. The treatments also rescued insulin resistance and low plasma leptin levels in SKO mice. Our findings demonstrate for the first time that\n                    <jats:italic>Seipin<\/jats:italic>\n                    deficiency induces renal injury, which is closely related to glucolipotoxicity and impaired renal reabsorption in SKO mice, and is primarily caused by the loss of AT and especially the lack of leptin. AT transplantation and leptin administration are two effective treatments for renal injury in\n                    <jats:italic>Seipin<\/jats:italic>\n                    \u2010deficient mice.\u2014Liu, X.\u2010J., Wu, X.\u2010Y., Wang, H., Wang, S.\u2010X., Kong, W., Zhang, L., Liu, G., Huang, W. Renal injury in\n                    <jats:italic>Seipin<\/jats:italic>\n                    \u2010deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue\u2010kidney crosstalk.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    32, 5550\u20135562 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201701427r","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T15:34:58Z","timestamp":1525793698000},"page":"5550-5562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Renal injury in\n                    <i>Seipin<\/i>\n                    \u2010deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue\u2010kidney crosstalk"],"prefix":"10.1096","volume":"32","author":[{"given":"Xue\u2010Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Sciences and Ministry of Education, Peking University Health Science Center Beijing China"},{"name":"Key Laboratory of Molecular Cardiovascular Science, Ministry of Education Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences and Ministry of Education, Peking University Health Science Center Beijing China"},{"name":"Key Laboratory of Molecular Cardiovascular Science, Ministry of Education Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of 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