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We found that M2\u2010like peritoneal macrophages from zymosan A\u2010treated mice exhibited a marked accumulation of Myc\u2010nick, a truncated protein generated by a Calpain\u2010mediated proteolytic cleavage of full\u2010 length c\u2010Myc. Further, ectopic expression of Myc\u2010nick in murine bone marrow\u2010derived macrophages promoted the M2 polarization and, consequently, enhanced their efferocytic capability. Notably, Myc\u2010nick\u2010induced efferocytosis was found to be tightly associated with \u03b1\u2010tubulin acetylation by K acetyltransferase 2a (Kat2a\/Gcn5) activity. These findings suggest Myc\u2010nick as a novel proresolving mediator that has a fundamental function in maintaining homeostasis under inflammatory conditions.\u2014Zhong, X., Lee, H.\u2010N., Kim, S. H., Park, S.\u2010A., Kim, W., Cha, Y.\u2010N., Surh, Y.\u2010J. Myc\u2010nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    32, 5312\u20135325 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800223r","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T16:09:25Z","timestamp":1525277365000},"page":"5312-5325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Myc\u2010nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation"],"prefix":"10.1096","volume":"32","author":[{"given":"Xiancai","family":"Zhong","sequence":"first","affiliation":[{"name":"Tumor Microenvironment Global Core Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha\u2010Na","family":"Lee","sequence":"additional","affiliation":[{"name":"Tumor Microenvironment Global Core Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Tumor Microenvironment Global Core Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University Seoul South Korea"},{"name":"Cancer Research Institute Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin\u2010Aye","family":"Park","sequence":"additional","affiliation":[{"name":"Tumor Microenvironment Global Core Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonki","family":"Kim","sequence":"additional","affiliation":[{"name":"Tumor Microenvironment Global Core Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Nam","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Joon","family":"Surh","sequence":"additional","affiliation":[{"name":"Tumor Microenvironment Global Core Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University Seoul South Korea"},{"name":"Cancer Research Institute Seoul National University Seoul South Korea"},{"name":"Department of Pharmacology and Toxicology, College of Medicine Inha University Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3253"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pharmthera.2013.04.006","article-title":"Resolution ofinflammation: mechanisms and opportunity for drug development","volume":"139","author":"Aessandri A. 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