{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:40:12Z","timestamp":1784310012023,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Infiltration of T cells is associated with patients who have diabetes at an increased risk of heart attack. T\u2010cell sphingosine 1\u2010phosphate receptor 1 (S1P\n                    <jats:sub>1<\/jats:sub>\n                    )\u2010mediated signaling directs T\u2010lymphocyte trafficking. Effects of T\u2010cell S1P\n                    <jats:sub>1<\/jats:sub>\n                    activation on cardiac fibrosis in a murine diabetic model remain to be explored. For this purpose, conditional T\u2010cell S1P\n                    <jats:sub>1<\/jats:sub>\n                    knockout (TS1P\n                    <jats:sub>1<\/jats:sub>\n                    KO) mice generated by crossing\n                    <jats:italic>\n                      S1pr\n                      <jats:sub>1<\/jats:sub>\n                      <jats:sup>loxP\/loxP<\/jats:sup>\n                    <\/jats:italic>\n                    mice with\n                    <jats:italic>Lck\u2010Cre<\/jats:italic>\n                    mice were used in a model of streptozotocin\u2010induced diabetic cardiomyopathy. The TS1P\n                    <jats:sub>1<\/jats:sub>\n                    KO mice exhibited sustained deficiency of both CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the blood. The TS1P\n                    <jats:sub>1<\/jats:sub>\n                    KO vehicle control mouse hearts featured an altered phenotype characterized by increased myocardial fibrosis and reduced cardiac contractility under normal levels of glucose. Compared with littermate diabetic mice, TS1P\n                    <jats:sub>1<\/jats:sub>\n                    KO diabetic mice had improved cardiac function and alleviated cardiac fibrosis detected after 11 wk of diabetic induction. Our results indicate that T\u2010cell S1P\n                    <jats:sub>1<\/jats:sub>\n                    signaling activation plays a dual role in the pathogenesis of cardiac fibrosis with respect to the levels of glucose: T\u2010cell S1P\n                    <jats:sub>1<\/jats:sub>\n                    activation exerts antifibrotic effects in normoglycemia but exacerbates fibrosis under hyperglycemia.\u2014Abdullah, C. S., Jin, Z.\u2010Q. Targeted deletion of T\u2010cell S1P receptor 1 ameliorates cardiac fibrosis in streptozotocin\u2010induced diabetic mice.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    32, 5426\u20135435 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800231r","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T13:50:37Z","timestamp":1524750637000},"page":"5426-5435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Targeted deletion of T\u2010cell S1P receptor 1 ameliorates cardiac fibrosis in streptozotocin\u2010induced diabetic mice"],"prefix":"10.1096","volume":"32","author":[{"given":"Chowdhury S.","family":"Abdullah","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy, South Dakota State University  Brookings South Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu\u2010Qiu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Biomedical Sciences College of Pharmacy, California Northstate University  Elk Grove California USA"},{"name":"Department of Pathology Louisiana State University Health Sciences Center Shreveport LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1349-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9131-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.12.011"},{"key":"e_1_2_7_7_1","first-page":"137","article-title":"Mechanisms of diabetic complications","volume":"93","author":"Forbes J. 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