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After myocardial infarction, macrophages predominantly clear the deceased cardiomyocyte apoptotic or necrotic neutrophils to develop a regenerative and reparative program with the activation of the lipoxygenase\u2010mediated maresin (MaR) metabolome at the site of ischemic injury. The specialized proresolving molecule and macrophage mediator in resolving inflammation, MaR\u20101, produced by human macrophages, has potent defining effects that limit polymorphonuclear neutrophil infiltration, enhance uptake of apoptotic PMNs, regulate inflammation resolution and tissue regeneration, and reduce pain. In addition to proresolving and antiinflammatory actions, MaR\u20101 displays potent tissue regenerative effects in stroke and is an antinociceptive. Macrophages actively participate in the biosynthesis of bioactive MaR\u20102, which exhibits anti\u2010inflammatory, proresolving, and atherosclerotic effects. A new class of macrophage\u2010derived molecules, MaR conjugates in tissue regeneration, is identified that regulates phagocytosis and the repair and regeneration of damaged tissue. The presented review provides a current summary of the effect of MaR in resolution pathophysiology, with relevance to a cardiac repair program.\u2014Jadapalli, J. K., Halade, G. V. Unified nexus of macrophages and maresins in cardiac reparative mechanisms.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    32, 5227\u20135237 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800254r","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T13:31:54Z","timestamp":1526045514000},"page":"5227-5237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Unified nexus of macrophages and maresins in cardiac reparative mechanisms"],"prefix":"10.1096","volume":"32","author":[{"given":"Jeevan Kumar","family":"Jadapalli","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Disease Department of Medicine The University of Alabama Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh V.","family":"Halade","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease Department of Medicine The University of Alabama Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.11.028"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0444-7"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00107"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303577"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00528.2017"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu025"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.04.012"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700109R"},{"key":"e_1_2_14_10_1","first-page":"187","article-title":"Neutrophils orchestrate post\u2010myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans M.","year":"2017","journal-title":"Eur. 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