{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:39:27Z","timestamp":1792532367323,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA12307"],"award-info":[{"award-number":["AA12307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["DK55532"],"award-info":[{"award-number":["DK55532"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pathogenesis of alcohol\u2010related diseases such as alcoholic hepatitis involves gut barrier dysfunction, endotoxemia, and toxin\u2010mediated cellular injury. Here we show that\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    not only blocks but also mitigates ethanol (EtOH)\u2010induced gut and liver damage in mice.\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    blocks EtOH\u2010induced protein thiol oxidation, and down\u2010regulation of antioxidant gene expression in colon\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    also blocks EtOH\u2010 induced expression of\n                    <jats:italic>TNF\u2010<\/jats:italic>\n                    \u03b1\n                    <jats:italic>, IL\u20101<\/jats:italic>\n                    \u03b2\n                    <jats:italic>, IL\u20106,<\/jats:italic>\n                    monocyte chemotactic protein 1 (MCP1), C\u2010X\u2010C motif chemokine ligand (CXCL)1, and\n                    <jats:italic>CXCL2<\/jats:italic>\n                    genes in colon. Epidermal growth factor receptor (EGFR) signaling mediates the\n                    <jats:italic>L. plantarum\u2010mediated<\/jats:italic>\n                    protection of tight junctions (TJs) and barrier function from acetaldehyde, the EtOH metabolite, in Caco\u20102 cell monolayers. In mice, doxycycline\u2010mediated expression of dominant negative EGFR blocks\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    \u2010mediated prevention of EtOH\u2010induced TJ disruption, mucosal barrier dysfunction, oxidative stress, and inflammatory response in colon.\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    blocks EtOH\u2010induced endotoxemia as well as EtOH\u2010induced pathologic lesions, triglyceride deposition, oxidative stress, and inflammatory responses in the liver by an EGFR\u2010 dependent mechanism.\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    treatment after injury accelerated recovery from EtOH\u2010induced TJ, barrier dysfunction, oxidative stress, and inflammatory response in colon, endotoxemia, and liver damage. Results dem onstrate that\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    has both preventive and therapeutic values in treatment of alcohol\u2010induced tissue injury, particularly in alcoholic hepatitis.\u2014Shukla, P. K., Meena, A. S., Manda, B., Gomes\u2010Solecki, M., Dietrich, P., Dragatsis, I., Rao, R.\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    prevents and mitigates alcohol\u2010induced disruption of colonic epi thelial tight junctions, endotoxemia, and liver damage by an EGF receptor\u2010dependent mechanism. 32, 6274\u20136292 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800351r","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T16:21:37Z","timestamp":1529338897000},"page":"6274-6292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["<i>Lactobacillus plantarum<\/i>\n                    prevents and mitigates alcohol\u2010induced disruption of colonic epithelial tight junctions, endotoxemia, and liver damage by an EGF receptor\u2010dependent mechanism"],"prefix":"10.1096","volume":"32","author":[{"given":"Pradeep K.","family":"Shukla","sequence":"first","affiliation":[{"name":"Department of Physiology University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avtar S.","family":"Meena","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargavi","family":"Manda","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gomes-Solecki","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Biochemistry University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Dragatsis","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RadhaKrishna","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2016.05.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2741\/3223"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38899"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom7010009","article-title":"Key events participating in the pathogenesis of alcoholic liver disease","volume":"7","author":"Magdaleno F.","year":"2017","journal-title":"Biomolecules"},{"key":"e_1_2_8_7_1","first-page":"170","article-title":"Probiotics for gastrointestinal conditions: a summary of the evidence","volume":"96","author":"Wilkins T.","year":"2017","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053028"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-205-43703"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2008.08.006"},{"key":"e_1_2_8_11_1","first-page":"510","article-title":"Engineering the microflora to vaccinate the mucosa: serum immunoglobulin G responses and activated draining cervical lymph nodes following mucosal application of tetanus toxin fragment C-expressing lactobacilli","volume":"100","author":"Shaw D. M.","year":"2000","journal-title":"Im munology"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00169-08"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005870"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28456"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1543809"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.35"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.04.013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MR0416-171R"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2012.09.039"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12865-017-0199-7","article-title":"Lipopolysaccharide mediates immuno-pathological alterations in young chicken liver through TLR4 signaling","volume":"18","author":"Huang X. Y.","year":"2017","journal-title":"BMC Immunol."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.08.012"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01673.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.2.G332"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02253.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085345"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.238147"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2012.0031"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.200902153","article-title":"Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.","volume":"189","author":"Marchiando A. M.","year":"2010","journal-title":"J. CellBiol."},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/13556219772840"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/37.4.322"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000125358.92335.90"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00464.2004"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201800351R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201800351R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201800351R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:35:27Z","timestamp":1761672927000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201800351R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,18]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1096\/fj.201800351R"],"URL":"https:\/\/doi.org\/10.1096\/fj.201800351r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,18]]},"assertion":[{"value":"2018-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}