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The objective of this work was to determine whether the effects of IGF\u2010I on growth and metabolism could be separated. We generated muscle\u2010specific IGF\u2010I\u2010deficient (MID) mice that afford inducible deletion of\n                    <jats:italic>Igf1<\/jats:italic>\n                    at any age. After\n                    <jats:italic>Igf1<\/jats:italic>\n                    deletion at birth or in young adult mice, evaluations of muscle physiology and glucose homeostasis were performed up to 16 wk of age. MID mice generated at birth had lower muscle and circulating IGF\u2010I, decreased muscle and body mass, and impaired muscle force production. Eight\u2010wk\u2010old male MID had heightened insulin levels with trends of elevated fasting glucose. This phenotype progressed to impaired glucose handling and increased fat deposition without significant muscle mass loss at 16 wk of age. The same phenotype emerged in 16\u2010wk\u2010old MID mice induced at 12 wk of age, compounded with heightened muscle fatigability and exercise intolerance. We assert that muscle IGF\u2010I independently modulates anabolism and metabolism in an age\u2010dependent manner, thus positioning muscle IGF\u2010I maintenance to be critical for both muscle growth and metabolic homeostasis.\u2014Vassilakos, G., Lei, H., Yang, Y., Puglise, J., Matheny, M., Durzynska, J., Ozery, M., Bennett, K., Spradlin, R., Bonanno, H., Park, S., Ahima, R. S., Barton, E. R. Deletion of muscle IGF\u2010I transiently impairs growth and progressively disrupts glucose homeostasis in male mice. FASEB J. 33, 181\u2013194 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800459r","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T17:18:45Z","timestamp":1529687925000},"page":"181-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Deletion of muscle IGF\u2010I transiently impairs growth and progressively disrupts glucose homeostasis in male mice"],"prefix":"10.1096","volume":"33","author":[{"given":"Georgios","family":"Vassilakos","sequence":"first","affiliation":[{"name":"Applied Physiology and Kinesiology College of Health and Human Performance University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqin","family":"Lei","sequence":"additional","affiliation":[{"name":"Applied Physiology and Kinesiology College of Health and Human Performance University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yang","sequence":"additional","affiliation":[{"name":"Pharmacology and Therapeutics College of Medicine University of Florida  Gainesville Florida USA"},{"name":"Gastrointestinal Surgery West China School of Medicine Sichuan University-West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Puglise","sequence":"additional","affiliation":[{"name":"Applied Physiology and Kinesiology College of Health and Human Performance University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Matheny","sequence":"additional","affiliation":[{"name":"Pharmacology and Therapeutics College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Durzynska","sequence":"additional","affiliation":[{"name":"Applied Physiology and Kinesiology College of Health and Human Performance University of Florida  Gainesville Florida USA"},{"name":"Molecular Virology Institute of Experimental Biology A. Mickiewicz University  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matan","family":"Ozery","sequence":"additional","affiliation":[{"name":"Applied Physiology and Kinesiology College of Health and Human Performance University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Bennett","sequence":"additional","affiliation":[{"name":"Applied Physiology and Kinesiology College of Health and Human Performance University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Spradlin","sequence":"additional","affiliation":[{"name":"Applied Physiology and Kinesiology College of Health and Human Performance University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Bonanno","sequence":"additional","affiliation":[{"name":"Animal Care Services Cancer and Genetics Research Complex University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soohyun","family":"Park","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rexford S.","family":"Ahima","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth R.","family":"Barton","sequence":"additional","affiliation":[{"name":"Applied Physiology and Kinesiology College of Health and Human Performance University of Florida  Gainesville Florida USA"},{"name":"Pharmacology and Therapeutics College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.54.5.311"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7324"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.12.7088"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.20.12109"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/84839"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200108071"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.1999.00618.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00479.2003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01405.2005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00230.2010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.5.1716"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080763"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2012.04.017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.A116.313201"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.13.3.228"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.04.037"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.908001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.12.9.0162"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00182.2008"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2015.11.001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1992"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-203026"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","unstructured":"Moorwood C. 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