{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:09:31Z","timestamp":1782302971237,"version":"3.54.5"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatocyte growth factor (HGF) is a multifunctional protein that contains angiogenic and neurotrophic properties. In the current study, we investigated the analgesic effects of HGF by using a plasmid DNA that was designed to express 2 isoforms of human HGF\u2014pCK\u2010HGF\u2010X7 (or VM202)\u2014in a chronic constriction injury (CCI)\u2010 induced mouse neuropathic pain model. Intramuscular injection of pCK\u2010HGF\u2010X7 into proximal thigh muscle induced the expression of HGF in the muscle, sciatic nerve, and dorsal root ganglia (DRG). This gene transfer procedure significantly attenuated mechanical allodynia and thermal hyperalgesia after CCI. Injury\u2010induced expression of activating transcription factor 3, calcium channel subunit \u03b12\u03b41, and CSF1 in the ipsilateral DRG neurons was markedly down\u2010regulated in the pCK\u2010HGF\u2010X7\u2010treated group, which suggested that HGF might exert its analgesic effects by inhibiting pain\u2010mediating genes in the sensory neurons. In addition, suppressed CSF1 expression in DRG neurons by pCK\u2010HGF\u2010X7 treatment was accompanied by a noticeable suppression of the nerve injury\u2010induced glial cell activation in the spinal cord dorsal horn. Taken together, our data show that pCK\u2010HGF\u2010X7 attenuates nerve injury\u2010induced neuropathic pain by inhibiting pain\u2010related factors in DRG neurons and subsequent spinal cord glial activation, which suggests its therapeutic efficacy in the treatment of neuropathic pain.\u2014Nho, B., Lee, J., Lee, J., Ko, K. R., Lee, S. J., Kim, S. Effective control of neuropathic pain by transient expression of hepatocyte growth factor in a mouse chronic constriction injury model. FASEB J. 32, 5119\u20135131 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800476r","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T16:01:06Z","timestamp":1524672066000},"page":"5119-5131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effective control of neuropathic pain by transient expression of hepatocyte growth factor in a mouse chronic constriction injury model"],"prefix":"10.1096","volume":"32","author":[{"given":"Boram","family":"Nho","sequence":"first","affiliation":[{"name":"School of Biological Sciences Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghun","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Seoul National University Seoul South Korea"},{"name":"ViroMed Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsub","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Ryang","family":"Ko","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Seoul National University Seoul South Korea"},{"name":"ViroMed Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Joong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Physiology Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Seoul National University Seoul South Korea"},{"name":"Department of Neuroscience and Physiology Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2005.04.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607043350107"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.3.629"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00418.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021283"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.49.273"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.3.3.513"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90080-U"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202379"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1603"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2010.101"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200105250-00022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(98)00019-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80466-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.24.3341"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3135-10.2010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-20-08369.1998"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80247-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.214"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.69"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.186"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2758"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090071"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000031827.16102.C1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.05.045"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2012.87"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00280.2008"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2483071579"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2010.05.003"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1614"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.21"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2015.110"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2016.1259334"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.05.004"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000265"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(98)00012-4"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42231-9"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.006"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0814"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2012.00007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.041574"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.12.014"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-06-01868.2001"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(01)00188-7"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4189"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153375"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.022"},{"key":"e_1_2_7_51_1","first-page":"629","article-title":"The role of the immune system in the generation of neuropathic pain","volume":"11","author":"Calvo M.","year":"2012","journal-title":"LancetNeurol."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2533"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.09.033"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.02.008"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-46450-2_8"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7065"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2003.06.002"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471143030.cb1514s46"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.11.002"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.021"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X07000403"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2518-14.2014"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201800476R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201800476R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201800476R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:45:33Z","timestamp":1761687933000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201800476R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1096\/fj.201800476R"],"URL":"https:\/\/doi.org\/10.1096\/fj.201800476r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,16]]},"assertion":[{"value":"2018-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}