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WAT aging in mice impairs cold\u2010induced beige adipocyte recruitment (beiging), which has been attributed to the senescence of adipose progenitor cells. Tumor suppressor p53 has also been implicated in WAT aging. However, whether p53\u2010related cellular aging in mature white adipocytes is causative of age\u2010impaired WAT beiging remains unknown. It is also unclear whether transient p53 inhibition can rescue WAT beiging. Herein, we report that p53 increased in adipose tissues of 28\u2010wk\u2010old (aged) mice with impaired beiging capability. Cold exposure decreased p53 in beiging WAT of young mice but not in aged mice. In aged mice, inducible p53 ablation in differentiated adipocytes restored cold\u2010induced WAT beiging and augmented whole\u2010body energy expenditure and insulin sensitivity. Transient pharmacological inhibition of p53 led to the same beneficial effects. Mechanistically, cold exposure repressed autophagy in beiging WAT of young mice yet increased autophagy in aged WAT. p53\u2010ablation reduced microtubule\u2010associated protein light chain 3\u2010mediated mitochondria clearance (mitophagy) and hence facilitated the increase of mitochondria during beiging. These findings suggest that p53\u2010induced mitophagy in aged white adipocytes impedes WAT beiging and may be therapeutically targeted to improve insulin sensitivity in aged WAT.\u2014Fu, W., Liu, Y., Sun, C., Yin, H. Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy. FASEB J. 33, 844\u2013856 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800577r","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T16:03:18Z","timestamp":1532707398000},"page":"844-856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy"],"prefix":"10.1096","volume":"33","author":[{"given":"Wenyan","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology The University of Georgia  Athens Georgia USA"},{"name":"Center for Molecular Medicine The University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology The University of Georgia  Athens Georgia USA"},{"name":"Center for Molecular Medicine The University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology The University of Georgia  Athens Georgia USA"},{"name":"Center for Molecular Medicine The University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3361"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810780"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049452"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0530"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68993"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0513"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.12.009"},{"key":"e_1_2_8_10_1","first-page":"35","article-title":"The distribution of brown adipose tissue in the human","volume":"112","author":"Heaton J. 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