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Here, we report the anti\u2010RSV activity of a small molecule, (1S,3R,4R,5R)\u20103,4\u2010\n                    <jats:italic>bis<\/jats:italic>\n                    {[(E)\u20103\u2010(3,4\u2010dihydroxyphenyl)prop\u20102\u2010enoyl]oxy}\u2010l,5\u2010dihydroxycyclohexane\u20101\u2010ca methyl ester (3,4\u2010DCQAME) or 3,4\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010Dicaffeoylquinic acid methyl ester, which can be isolated from several plants of traditional Chinese medicine. We showed for the first time that compound 3,4\u2010DCQAME potently inhibits RSV entry and infection.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , 3,4\u2010DCQAME can interact with F(ecto), the ectodomain of RSV fusion (F) protein. In cultured cells, the compound can block the interaction of F(ecto) protein with the cellular membrane and inhibit viral fusion during RSV entry, leading to inhibition of viral gene expression and infection. In RSV\u2010infected mice that were treated with 3,4\u2010DCQAME, we observed a reduction of RSV\u2010induced pathologic changes and substantial inhibition of viral infection and growth in the lung tissues. Our results provide the first direct evidence of the anti\u2010RSV activity of 3,4\u2010DCQAME. Furthermore, these results suggest that 3,4\u2010DCQAME represents a promising lead compound for anti\u2010RSV therapeutic development.\u2014Tang, W., Li, M., Liu, Y., Liang, N., Yang, Z., Zhao, Y., Wu, S., Lu, S., Li, Y., Liu, F. Small molecule inhibits respiratory syncytial virus entry and infection by blocking the interaction of the viral fusion protein with the cell membrane. FASEB J. 33, 4287\u20134299 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800579r","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T14:36:52Z","timestamp":1545316612000},"page":"4287-4299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Small molecule inhibits respiratory syncytial virus entry and infection by blocking the interaction of the viral fusion protein with the cell membrane"],"prefix":"10.1096","volume":"33","author":[{"given":"Wei","family":"Tang","sequence":"first","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of Pharmacy Jinan University  Guangzhou China"},{"name":"School of Public Health University of California-Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manmei","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health University of California-Berkeley  Berkeley California USA"},{"name":"School of Medicine St. George's University  Grenada, West Indies"},{"name":"Guangzhou Qinheli Biotechnolgies Incorporated  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangzhou Qinheli Biotechnolgies Incorporated  Guangzhou Guangdong China"},{"name":"Jiangsu Affynigen Biotechnolgies Incorporated  Taizhou Jiangsu China"},{"name":"Taizhou Institute of Virology  Taizhou Jiangsu China"},{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Applied Biology and Chemical Technology State Key Laboratory of Chirosciences Hong Kong Polytechnic University  Kowloon Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Applied Biology and Chemical Technology State Key Laboratory of Chirosciences Hong Kong Polytechnic University  Kowloon Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangwei","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Public Health University of California-Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaolan","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of Pharmacy Jinan University  Guangzhou China"},{"name":"School of Public Health University of California-Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9906076"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000813"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200205000-00037"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728210902946399"},{"key":"e_1_2_8_6_1","first-page":"235","article-title":"Respiratory syncytial virus disease: prevention and treatment","volume":"372","author":"Chu H. 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