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Therefore, divergent strategies aiming at the\n                    <jats:italic>de novo<\/jats:italic>\n                    formation of contractile tissue, as a prerequisite for the restoration of cardiac pump function, are currently being pursued. Clinical trials involving the transplantation of somatic progenitor cells failed. The search for alternative cell\u2010based strategies to combat the consequences of ischemic injury has sparked widespread interest in the genetic and pharmacologic reprogramming of fibroblasts into cardiomyocytes, harnessing the abundant\n                    <jats:italic>in vivo<\/jats:italic>\n                    pool of cardiac fibroblasts. Here, we provide a comprehensive overview of\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    cardiac reprogramming studies identified in an extensive literature search. We systematically review and evaluate feasibility, efficiency, and reproducibility of the different technologies currently being explored. Finally, we discuss potential safety issues deduced from preclinical studies and identify obstacles that must be overcome before clinical translation.\u2014Klose, K., Gossen, M., Stamm, C. Turning fibroblasts into cardiomyocytes: technological review of cardiac transdifferentiation strategies. FASEB J. 33, 49\u201370 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800712r","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T16:05:31Z","timestamp":1536249931000},"page":"49-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Turning fibroblasts into cardiomyocytes: technological review of cardiac transdifferentiation strategies"],"prefix":"10.1096","volume":"33","author":[{"given":"Kristin","family":"Klose","sequence":"first","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies (BCRT)  Berlin Germany"},{"name":"Berlin-Brandenburg School for Regenerative Therapies (BSRT)  Berlin Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Gossen","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies (BCRT)  Berlin Germany"},{"name":"Helmholtz\u2010Zentrum Geesthacht (HZG) Institute of Biomaterial Science  Teltow Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Stamm","sequence":"additional","affiliation":[{"name":"Berlin-Brandenburg Center for Regenerative Therapies (BCRT)  Berlin Germany"},{"name":"Berlin-Brandenburg School for Regenerative Therapies (BSRT)  Berlin Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"German Centre for Cardiovascular Research (DZHK) Partner Site Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum Berlin (DHZB)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368907783338235"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.08.077"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-817981"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12110-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.07.022"},{"key":"e_1_2_9_8_1","article-title":"Stem cell treatment for acute myocardial infarction","volume":"9","author":"Fisher S. 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