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As an m\n                    <jats:sup>6<\/jats:sup>\n                    A writer, the methyltransferase\u2010like 3\u2010methyltransferase\u2013like 14 (METTL14)\u2013Wilms tumor 1\u2013associated protein complex dynamically regulates m\n                    <jats:sup>6<\/jats:sup>\n                    A modification and plays important roles in diverse biologic processes. However, our knowledge about the complete functions of this RNA methyltransferase complex, the contributions of each component to the methylation, and their effects on different biologic pathways are still limited. By using both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    models, we here report that METTL14 is indispensable for postimplantation embryonic development by facilitating the conversion from naive to primed state of the epiblast. Depletion of\n                    <jats:italic>Mettl14<\/jats:italic>\n                    leads to conspicuous embryonic growth retardation from embryonic d 6.5, mainly as a result of resistance to differentiation, which further leads to embryonic lethality early in gestation. Our data highlight the critical function of METTL14 as an m\n                    <jats:sup>6<\/jats:sup>\n                    A modification regulator in orchestrating early mouse embryogenesis.\u2014Meng, T.\u2010G., Lu, X., Guo, L., Hou, G.\u2010M., Ma, X.\u2010S., Li, Q.\u2010N., Huang, L., Fan, L.\u2010H., Zhao, Z.\u2010H, Ou, X.\u2010H., OuYang, Y.\u2010C., Schatten, H., Li, L., Wang, Z.\u2010B., Sun, Q.\u2010Y. Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. FASEB J. 33, 1179\u20131187 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800719r","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T15:45:39Z","timestamp":1534347939000},"page":"1179-1187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["<i>Mettl14<\/i>\n                    is required for mouse postimplantation development by facilitating epiblast maturation"],"prefix":"10.1096","volume":"33","author":[{"given":"Tie-Gang","family":"Meng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing 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