{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:43:56Z","timestamp":1790991836330,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK064732"],"award-info":[{"award-number":["DK064732"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS091830"],"award-info":[{"award-number":["NS091830"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In humans, vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficiency causes peripheral and CNS manifestations. Loss of myelin in the peripheral nerves and the spinal cord (SC) contributes to peripheral neuropathy and motor deficits. The metabolic basis for the demyelination and brain disorder is unknown. The transcobalamin receptor\u2013knockout mouse (\n                    <jats:italic>\n                      Cd320\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    ) develops cobalamin (Cb1) deficiency in the nervous system, with mild anemia. A decreased\n                    <jats:italic>S<\/jats:italic>\n                    \u2010adenosylme\u2010thionine:S\u2010adenosylhomocysteine ratio and increased methionine were seen in the brain with no significant changes in neurotransmitter metabolites. The structural pathology in the SC presented as loss of myelin in the axonal tracts with inflammation. The sciatic nerve (SN) showed increased nonuniform, internodal segments suggesting demyelination, and remyelination in progress. Consistent with these changes, the\n                    <jats:italic>\n                      Cd320\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mouse showed an increased latency to thermal nociception. Further, lower amplitude of compound action potential in the SN suggested that the functional capacity of the heavily myelinated axons were preferentially compromised, leading to loss of peripheral sensation. Although the metabolic basis for the demyelination and the structural and functional alterations of the nervous system in Cb1 deficiency remain unresolved, the\n                    <jats:italic>\n                      Cd320\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mouse provides a unique model to investigate the pathologic consequences of vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficiency.\u2014Arora, K., Sequeira, J. M., Alarcon, J. M., Wasek, B., Arning, E., Bottiglieri, T., Quadros, E. V. Neuropathology of vitamin B12 deficiency in the Cd320\u2212\/\u2212 mouse. FASEB J. 33, 2563\u20132573 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800754rr","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T14:13:12Z","timestamp":1539180792000},"page":"2563-2573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Neuropathology of vitamin B\n                    <sub>12<\/sub>\n                    deficiency in the\n                    <i>\n                      Cd320\n                      <sup>\u2212\/\u2212<\/sup>\n                    <\/i>\n                    mouse"],"prefix":"10.1096","volume":"33","author":[{"given":"Kaveri","family":"Arora","sequence":"first","affiliation":[{"name":"The School of Graduate Studies State University of New York (SUNY) Downstate Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Department of Medicine State University of New York (SUNY) Downstate Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Alarcon","sequence":"additional","affiliation":[{"name":"Department of Pathology State University of New York (SUNY) Downstate Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandi","family":"Wasek","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Disease Baylor Research Institute Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erland","family":"Arning","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Disease Baylor Research Institute Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodoro","family":"Bottiglieri","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Disease Baylor Research Institute Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward V.","family":"Quadros","sequence":"additional","affiliation":[{"name":"Department of Medicine State University of New York (SUNY) Downstate Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline","author":"Institute of Medicine; Food and Nutrition Board; A Report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients","year":"1998"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1967.tb01632.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"F408","DOI":"10.1152\/ajprenal.00206.2000","article-title":"Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12)","volume":"282","author":"Birn H.","year":"2002","journal-title":"Am. 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