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Cumambrin A is a natural compound isolated from\n                    <jats:italic>Chrysanthemum indicum<\/jats:italic>\n                    L. and belongs to a member of the sesquiterpene lactone family. To date, the therapeutic effect of cumambrin A on osteoporosis and its mechanisms of action are not known. In this study, we found that cumambrin A can significantly inhibit osteoclast formation and bone resorption through the suppression of receptor activator of NF\u2010\u03baB ligand (RANKL)\u2013induced NF\u2010\u03baB and nuclear factor of activated T\u2010cell activity and ERK phosphorylation. Furthermore, cumambrin A inhibits the expression of osteoclast marker genes including cathepsin K, calcitonin receptor, and V\u2010ATPase d2. Using an\n                    <jats:italic>in vivo<\/jats:italic>\n                    ovariectomized mouse model, we showed that cumambrin A protects against estrogen withdrawal\u2013induced bone loss. Collectively, our results reveal that cumambrin A can suppress osteoclast formation, bone resorption, and RANKL\u2010induced signaling pathways, suggesting that cumambrin A is a potential therapeutic agent for the treatment of osteoporosis.\u2014Zhou, L., Liu, Q., Hong, G., Song, F., Zhao, J., Yuan, J., Xu, J., Tan, R. X., Tickner, J., Gu, Q., Xu, J. Cumambrin A prevents OVX\u2010induced osteoporosis\n                    <jats:italic>via<\/jats:italic>\n                    the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways. FASEB J. 33, 6726\u20136735 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201800883rrr","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T14:36:48Z","timestamp":1551191808000},"page":"6726-6735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cumambrin A prevents OVX\u2010induced osteoporosis\n                    <i>via<\/i>\n                    the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways"],"prefix":"10.1096","volume":"33","author":[{"given":"Lin","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Department of Endocrinology The Fifth Affiliated Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Research Centre for Regenerative Medicine Guangxi Medical University Nanning China"},{"name":"Guangxi Key Laboratory of Regenerative Medicine Guangxi Medical University Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoju","family":"Hong","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Orthopedic Department The First Affiliated Hospital Guangzhou University of Chinese Medicine Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangming","family":"Song","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Research Centre for Regenerative Medicine Guangxi Medical University Nanning China"},{"name":"Guangxi Key Laboratory of Regenerative Medicine Guangxi Medical University Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinmin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Research Centre for Regenerative Medicine Guangxi Medical University Nanning China"},{"name":"Guangxi Key Laboratory of Regenerative Medicine Guangxi Medical University Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbo","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"Research Center for Drug Discovery School of Pharmaceutical Sciences Sun Yat-Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren Xiang","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional Biomolecules Nanjing University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Tickner","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Gu","sequence":"additional","affiliation":[{"name":"Research Center for Drug Discovery School of Pharmaceutical Sciences Sun Yat-Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiake","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1504"},{"key":"e_1_2_8_4_1","first-page":"929","article-title":"Absolute measurement of total-body calcium by the Ar-37 method-preliminary results: concise communication","volume":"18","author":"Lewellen T. 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