{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:01:41Z","timestamp":1792641701877,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2017YFA0105101"],"award-info":[{"award-number":["2017YFA0105101"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2014B020225003"],"award-info":[{"award-number":["2014B020225003"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Pure hair and nail ectodermal dysplasia 9 (ECTD\u20109) is an autosomal recessive genetic disease caused by mutation of\n HOXC13<\/jats:italic>\n and is characterized by hypotrichosis and nail dystrophy in humans. Unlike patients with ECTD\u20109,\n Hoxc13<\/jats:italic>\n \u2010mutated mice and pigs do not faithfully recapitulate the phenotype of hypotrichosis, so there is a limited understanding of the molecular mechanism of\n Hoxc13<\/jats:italic>\n \u2010mediated hypotrichosis in animal models and clinically. Here, the homozygous\n \n Hoxc13\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n rabbits showed complete loss of hair on the head and dorsum, whereas hypotrichosis in the limbs and tail were determined in the\n \n Hoxc13\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n rabbits. In addition, reduced hair follicles (HFs) while the enlarged and increased number of sebaceous glands (SGs) were also found in the\n \n Hoxc13\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n rabbits, showing that the disrupted balance between HFs and SGs may respond to hypotrichosis of ECTD\u20109 in an animal model and clinically. Therefore, our findings demonstrate that\n \n Hoxc13\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n rabbits can be used as a model for human ECTD\u20109, especially to understand the pathologic mechanism of hypotrichosis. Moreover, the disrupted balance between HFs and SGs, especially in the\n \n Hoxc13\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n rabbits, can be used as an ideal animal model for dermatology ailments, such as acne and hypotrichosis, in preclinical studies.\u2014Deng, J., Chen, M., Liu, Z., Song, Y., Sui, T., Lai, L., Li, Z. The disrupted balance between hair follicles and sebaceous glands in\n Hoxc13<\/jats:italic>\n \u2010ablated rabbits. FASEB J. 33, 1226\u20131234 (2019).\n www.fasebj.org<\/jats:ext-link>\n <\/jats:p>","DOI":"10.1096\/fj.201800928rr","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T15:30:45Z","timestamp":1534779045000},"page":"1226-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The disrupted balance between hair follicles and sebaceous glands in\n Hoxc13<\/i>\n \u2010ablated rabbits"],"prefix":"10.1096","volume":"33","author":[{"given":"Jichao","family":"Deng","sequence":"first","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Chen","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiquan","family":"Liu","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Song","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Sui","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangxue","family":"Lai","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis Jilin University Changchun China"},{"name":"Key Laboratory of Regenerative Biology South China Institute for Stem Cell Biology and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine South China Institute for Stem Cell Biology and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanjun","family":"Li","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of Zoonosis Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00005.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.04.039"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12889"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.10.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12302"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22271"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.08.029"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-017-0402-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13115"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00114-003-0417-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.9.1547"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.391"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603646200"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10114.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404331200"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.1.11"},{"key":"e_1_2_9_18_1","first-page":"184","article-title":"Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9","volume":"26","author":"Han K.","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-9769-3-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15830-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231143"},{"key":"e_1_2_9_22_1","first-page":"2661","article-title":"CRISPR\/Cas9-mediated mutation of PHEX in rabbit recapitulates human X-linked hypophosphatemia (XLH)","volume":"25","author":"Sui T.","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1545-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2143-z"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4103\/ijt.ijt_100_16","article-title":"Scanning electron microscopy and X-ray microanalysis of reconstructive hair fibers","volume":"9","author":"Combalia A.","year":"2017","journal-title":"Int. J. Trichology"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2003.00142.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23185"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2312-7"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90487-5"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6408(1998)22:4<301::AID-DVG1>3.0.CO;2-A"},{"key":"e_1_2_9_31_1","first-page":"127","article-title":"Craniofacial development of avian and rodent embryos","volume":"135","author":"Hall B. K.","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194203000-00015"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(06)51006-X"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700734"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0435-6"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.572511"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630050517739-1"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-017-1795-3"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201800928RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201800928RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201800928RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:44:19Z","timestamp":1786707859000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201800928RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,20]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1096\/fj.201800928RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.201800928rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,20]]},"assertion":[{"value":"2018-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}