{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:32:41Z","timestamp":1786710761366,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008549","name":"Shanxi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vitamin D is known to play a protective role in inflammatory diseases. Although the suppressive effect of vitamin D\/vitamin D receptor (VDR) signaling has been shown in the context of oral lichen planus (OLP), the molecular basis of its regulatory function remains poorly understood. Herein, we reported that miR\u2010802 over\u2010expression in OLP could aggravate apoptosis of oral keratinocytes by targeting B\u2010cell lymphoma 2 mRNA. In addition, vitamin D\/VDR signaling was able to suppress miR\u2010802 expression in LPS\u2010treated or activated CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010stimulated human oral keratinocytes by blocking NF\u2010\u03baB pathways, thereby inhibiting OLP apoptosis. Consistent with the results\n                    <jats:italic>in vitro<\/jats:italic>\n                    , we showed that miR\u2010802 expression was enhanced in oral keratinocytes from VDR\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice, and an inverse correlation between VDR and miR\u2010802 was found in human biopsy specimens of OLP. Collectively, our data suggest that vitamin D\/VDR signaling suppresses oral keratinocyte apoptosis by targeting miR\u2010802.\u2014Zhao, B., Xu, N., Li, R., Yu, F., Zhang, F., Yang, F., Ge, X., Li, Y. C., Du, J. Vitamin D\/VDR signaling suppresses microRNA\u2010802\u2010induced apoptosis of keratinocytes in oral lichen planus. FASEB J. 33, 1042\u20131050 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801020rrr","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T15:47:16Z","timestamp":1533311236000},"page":"1042-1050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Vitamin D\/VDR signaling suppresses microRNA\u2010802\u2010induced apoptosis of keratinocytes in oral lichen planus"],"prefix":"10.1096","volume":"33","author":[{"given":"Bin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Chun","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences Department of Medicine The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology  Taiyuan China"},{"name":"Division of Biological Sciences Department of Medicine The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2014.01.001"},{"key":"e_1_2_9_3_1","first-page":"259","article-title":"Oral lichen planus update: clinical characteristics, treatment responses, and malignant transformation","volume":"10","author":"Silverman S.","year":"1997","journal-title":"Am. 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