{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:18:06Z","timestamp":1790680686173,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK98055-06"],"award-info":[{"award-number":["R01DK98055-06"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetic foot ulcers (DFUs) are a major complication of diabetes, and there is a critical need to develop novel cell\u2010 and tissue\u2010based therapies to treat these chronic wounds. Induced pluripotent stem cells (iPSCs) offer a replenishing source of allogeneic and autologous cell types that may be beneficial to improve DFU wound\u2010healing outcomes. However, the biologic potential of iPSC\u2010derived cells to treat DFUs has not, to our knowledge, been investigated. Toward that goal, we have performed detailed characterization of iPSC\u2010derived fibroblasts from both diabetic and nondiabetic patients. Significantly, gene array and functional analyses reveal that iPSC\u2010derived fibroblasts from both patients with and those without diabetes are more similar to each other than were the primary cells from which they were derived. iPSC\u2010derived fibroblasts showed improved migratory properties in 2\u2010dimensional culture. iPSC\u2010derived fibroblasts from DFUs displayed a unique biochemical composition and morphology when grown as 3\u2010dimensional (3D), self\u2010assembled extracellular matrix tissues, which were distinct from tissues fabricated using the parental DFU fibroblasts from which they were reprogrammed.\n                    <jats:italic>In vivo<\/jats:italic>\n                    transplantation of 3D tissues with iPSC\u2010derived fibroblasts showed they persisted in the wound and facilitated diabetic wound closure compared with primary DFU fibroblasts. Taken together, our findings support the potential application of these iPSC\u2010derived fibroblasts and 3D tissues to improve wound healing.\u2014Kashpur, O., Smith, A., Gerami\u2010Naini, B., Maione, A. G., Calabrese, R., Tellechea, A., Theocharidis, G., Liang, L., Pastar, I., Tomic\u2010Canic, M., Mooney, D., Veves, A., Garlick, J. A. Differentiation of diabetic foot ulcer\u2013derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes. FASEB J. 33, 1262\u20131277 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801059","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T14:04:26Z","timestamp":1533737066000},"page":"1262-1277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Differentiation of diabetic foot ulcer\u2013derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes"],"prefix":"10.1096","volume":"33","author":[{"given":"Olga","family":"Kashpur","sequence":"first","affiliation":[{"name":"Department of Diagnostic Sciences School of Dental Medicine Tufts University  Boston Massachusetts 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