{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:33:35Z","timestamp":1780472015154,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470572"],"award-info":[{"award-number":["81470572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771272"],"award-info":[{"award-number":["31771272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770678"],"award-info":[{"award-number":["81770678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The vasoconstrictor and\/or pressor effects of prostaglandin (PG)F\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    participate in the development of vascular pathologies and limit the clinical use of the agent. This study aimed to determine the receptor types responsible for the vasoconstrictor activity of PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    and whether they mediate the pressor response evoked by the prostanoid under\n                    <jats:italic>in vivo<\/jats:italic>\n                    conditions. Experiments were performed on genetically altered mice and\/or on vessels from these mice or humans. Here we show that deletion of the thromboxane\u2010prostanoid receptor (TP\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) abolished or drastically diminished the contraction to PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    in isolated mouse vessels (some of which were resistance arteries) and reduced the elevation in blood pressure evoked by the prostanoid under\n                    <jats:italic>in vivo<\/jats:italic>\n                    conditions. In accordance, TP antagonism abolished the contraction in small arteries of human omentum. Further deletion of E prostanoid receptor type 3 (EP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) removed the PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    \u2010evoked contraction that remained in some TP\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    arteries and added to the effect of TP\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    on the elevation in blood pressure evoked by the prostanoid under\n                    <jats:italic>in vivo<\/jats:italic>\n                    conditions. In contrast, the uterine contraction to PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    mediated\n                    <jats:italic>via<\/jats:italic>\n                    the F prostanoid receptor (FP) was unaltered in TP\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    \/EP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. These results demonstrate that the non\u2010FP receptors TP and\/or EP3 mediate the vasoconstrictor and pressor effects of PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    , which are still of concern under clinical conditions.\u2014Liu, B., Li, J., Yan, H., Tian, D., Li, H., Zhang, Y., Guo, T., Wu, X., Luo, W., Zhou, Y. TP and\/or EP3 receptors mediate the vasoconstrictor and pressor responses of prostaglandin F\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    in mice and\/or humans. FASEB J. 33, 2451\u20132459 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801064rr","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T15:49:40Z","timestamp":1538495380000},"page":"2451-2459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["TP and\/or EP3 receptors mediate the vasoconstrictor and pressor responses of prostaglandin F\n                    <sub>2\u03b1<\/sub>\n                    in mice and\/or humans"],"prefix":"10.1096","volume":"33","author":[{"given":"Bin","family":"Liu","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center Shantou University Medical College Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shantou University Medical College Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pathology The Affiliated Cancer Hospital Shantou University Medical College Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pathology Shantou University Medical College Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"The Central Laboratory Shantou University Medical College Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shantou University Medical College Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Guo","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shantou University Medical College Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shantou University Medical College Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Luo","sequence":"additional","affiliation":[{"name":"The Central Laboratory Shantou University Medical College Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shantou University Medical College Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00441.2002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(87)90192-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11875"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5326.681"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod62.3.533"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.02.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6934(03)00069-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14489.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j3875"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.179770"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811834106"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2017.06.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000163145.12707.63"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2001.0410"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3874"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706390"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42167"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1982.tb09236.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.062034"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09288-w"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.08.015"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1193"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00226.2005"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm112"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00604.2011"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.165100"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00423.2003"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.03.043"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00150.2015"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.10.040"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000298881"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)22892-0"},{"key":"e_1_2_8_34_1","first-page":"H1538","article-title":"Prostaglandin F2 alpha-induced endothelium-dependent relaxation in isolated monkey cerebral arteries","volume":"260","author":"Kawai Y.","year":"1991","journal-title":"Am. J. Physiol."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365519209088778"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198803000-00014"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15960.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12465.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb09063.x"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201801064RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201801064RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201801064RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:15:57Z","timestamp":1761700557000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201801064RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1096\/fj.201801064RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.201801064rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,2]]},"assertion":[{"value":"2018-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}