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Although dysfunctional signaling transduction is attributed to airway inflammation, the exact mechanism of airway remodeling remains largely unknown. TRPC1, a member of the transient receptor potential canonical Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel family, possesses versatile functions but its role in airway remodeling remains undefined. Here, we show that ablation of TRPC1 in mice alleviates airway remodeling following house dust mite (HDM) challenge with decreases in mucus production, cytokine secretion, and collagen deposition. HDM challenge induces Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx via the TRPC1 channel, resulting in increased levels of signal transducer and activator of transcription 3 (STAT3) and proinflammatory cytokines. In contrast, STAT3 expression was significantly decreased in TRPC1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mouse lungs compared with wild\u2010type controls after HDM challenge. Mechanistically, STAT3 promotes epithelial\u2010to\u2010mesenchymal transition and increases mucin 5AC expression. Collectively, these findings identify TRPC1 as a modulator of HDM\u2010induced airway remodeling\n                    <jats:italic>via<\/jats:italic>\n                    STAT3\u2010mediated increase in mucus production, which provide new insight in our understanding of the molecular basis of airway remodeling, and identify novel therapeutic targets for intervention of severe chronic asthma.\u2014Pu, Q., Zhao, Y., Sun, Y., Huang, T., Lin, P., Zhou, C., Qin, S., Singh, B. B., Wu, M TRPC1 intensifies house dust mite\u2013induced airway remodeling by facilitating epithelial\u2010to\u2010mesenchymal transition and STAT3\/NF\u2010\u03baB signaling. FASEB J. 33, 1074\u20131085 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801085r","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T13:09:39Z","timestamp":1533128979000},"page":"1074-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["TRPC1 intensifies house dust mite\u2013induced airway remodeling by facilitating epithelial\u2010to\u2010mesenchymal transition and STAT3\/NF\u2010\u03baB signaling"],"prefix":"10.1096","volume":"33","author":[{"given":"Qinqin","family":"Pu","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences School of Medicine and Health Sciences University of North Dakota  Grand Forks North Dakota USA"},{"name":"State Key Laboratory of Biotherapy West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences School of Medicine and Health Sciences University of North Dakota  Grand Forks North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences School of Medicine and Health Sciences University of North Dakota  Grand Forks North Dakota USA"},{"name":"University of Texas Health Science Center at San Antonio  San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences School of Medicine and Health Sciences University of North Dakota  Grand Forks North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences School of Medicine and Health Sciences University of North Dakota  Grand Forks North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanmin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences School of Medicine and Health Sciences University of North Dakota  Grand Forks North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shugang","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences School of Medicine and Health Sciences University of North Dakota  Grand Forks North Dakota USA"},{"name":"State Key Laboratory of Biotherapy West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brij B.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences School of Medicine and Health Sciences University of North Dakota  Grand Forks North Dakota USA"},{"name":"University of Texas Health Science Center at San Antonio  San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences School of Medicine and Health Sciences University of North Dakota  Grand Forks North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2010.2.3.172"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.05.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.4.310"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.4.916"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90067-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(96)80227-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200306-727OC"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/318029"},{"key":"e_1_2_8_10_1","first-page":"117","article-title":"The use of a screening questionnaire to identify children with likely asthma","volume":"51","author":"Frank P. 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