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Mutations in TZ proteins result in cilia dysfunction, often causing pleiotropic effects observed in a group of human diseases classified as ciliopathies. The purpose of this study is to describe the importance of the TZ component Meckel\u2010Gr\u00fcber syndrome 6 (\n                    <jats:italic>Mks6<\/jats:italic>\n                    ) in several organ systems and tissues regarding ciliogenesis and cilia maintenance using congenital and conditional mutant mouse models. Similar to MKS, congenital loss of\n                    <jats:italic>Mks6<\/jats:italic>\n                    is embryonic lethal, displaying cilia loss and altered cytoskeletal microtubule modifications but only in specific cell types. Conditional\n                    <jats:italic>Mks6<\/jats:italic>\n                    mutants have a variable cystic kidney phenotype along with severe retinal degeneration with mislocalization of phototransduction cascade proteins. However, other phenotypes, such as anosmia and obesity, which are typically associated with cilia and TZ dysfunction, were not evident. These data indicate that despite Mks6 being a core TZ component, it has tissue\u2010 or cell type\u2010specific functions important for cilia formation and cilia sensory and signaling activities.\u2014Lewis, W. R., Bales, K. L., Revell, D. Z., Croyle, M. J., Engle, S. E., Song, C. J., Malarkey, E. B., Uytingco, C. R., Shan, D., Antonellis, P. J., Nagy, T. R., Kesterson, R. A., Mrug, M. M., Martens, J. R., Berbari, N. F., Gross, A. K., Yoder, B. K. Mks6 mutations reveal tissue\u2010 and cell type\u2010specific roles for the cilia transition zone. FASEB J. 33, 1440\u20131455 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801149r","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T14:17:39Z","timestamp":1534947459000},"page":"1440-1455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Mks6 mutations reveal tissue\u2010 and cell type\u2010specific roles for the cilia transition zone"],"prefix":"10.1096","volume":"33","author":[{"given":"Wesley R.","family":"Lewis","sequence":"first","affiliation":[{"name":"Department of Cell, Developmental, and Integrative Biology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie 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