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However, the regeneration mechanism has not been fully clarified. This study investigated the role of transcriptional coactivator with PDZ\u2010binding motif (TAZ), a Hippo\u2010signaling effector, in liver regeneration. We observed that TAZ stimulates liver regeneration after liver injury. After partial hepatectomy (PHx) or carbon tetrachloride damage, TAZ was required for liver regeneration to increase hepatic cell proliferation and resist hepatic apoptosis, which were decreased in liver\u2010specific TAZ knockout (LKO) mice. TAZ stimulated macrophage infiltration, resulting in IL\u20106 production, which induced liver regeneration. In LKO mice, IL\u20106\u2013induced activation of signal transducer and activator of transcription 3, ERK, and PKB was decreased. We also observed that periductal fibrogenesis was significantly increased in LKO mice during liver regeneration after PHx, which was caused by increased hepatic apoptosis. Our results suggest that TAZ stimulates liver regeneration through IL\u20106\u2013induced hepatocyte proliferation and inhibition of cell death after liver injury.\u2014Kim, A. R., Park, J. I., Oh, H. T., Kim, K. M., Hwang, J.\u2010H., Jeong, M. G., Kim, E.\u2010H., Hwang, E. S., Hong, J.\u2010H. TAZ stimulates liver regeneration through interleukin\u20106\u2013induced hepatocyte proliferation and inhibition of cell death after liver injury. FASEB J. 33, 5914\u20135923 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801256rr","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T18:58:28Z","timestamp":1549911508000},"page":"5914-5923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["TAZ stimulates liver regeneration through interleukin\u20106\u2013induced hepatocyte proliferation and inhibition of cell death after liver injury"],"prefix":"10.1096","volume":"33","author":[{"given":"A Rum","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Life Sciences School of Life Sciences and Biotechnology Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung","family":"I1 Park","sequence":"additional","affiliation":[{"name":"Department of Life Sciences School of Life Sciences and Biotechnology Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Taek","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Life Sciences School of Life Sciences and Biotechnology Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Sciences School of Life Sciences and Biotechnology Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Ha","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Life Sciences School of Life Sciences and Biotechnology Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Gyeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ewha Womans University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ewha Womans University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Sook","family":"Hwang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ewha Womans University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Life Sciences School of Life Sciences and Biotechnology Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.60"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20969"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1489"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201000085"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.97"},{"key":"e_1_2_8_7_1","first-page":"186","article-title":"Experimental pathology of the liver. 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