{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:02:44Z","timestamp":1787162564746,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30971245"],"award-info":[{"award-number":["30971245"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000112"],"award-info":[{"award-number":["81000112"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    C1q\/tumor necrosis factor\u2010related protein 13 (CTRP13) is a secreted adipokine that can ameliorate abnormal glucose and lipid metabolism. However, the functional role of CTRP13 in the development of atherosclerotic plaques has yet to be described. In this study, we collected blood samples from patients of coronary artery diseases and apolipoprotein E (ApoE)\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice that were fed a Western diet for 12 wk to induce atherosclerosis and found that serum CTRP13 level was decreased.\n                    <jats:italic>En face<\/jats:italic>\n                    staining of aortas and aortic sinus in ApoE\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice showed that ectopic CTRP13 infusion\n                    <jats:italic>in vivo<\/jats:italic>\n                    dramatically decreased lesion areas, as well as reduced inflammatory responses with less macrophage content. In primary peritoneal macrophages\n                    <jats:italic>in vitro<\/jats:italic>\n                    , CTRP13 supplement reduced oxidized LDL uptake, foam\u2010cell formation, and trapping, together with the suppressed cluster of differentiation 36 (CD36) protein levels. Reduced CD36 protein level was attributed to the autophagy\u2010lysosome\u2010dependent degradation of CD36 at the post\u2010transcriptional level. The blocking of autophagy\u2010lysosome induction could increase CD36 protein level, foam\u2010cell formation, and migration, thus abolishing the protective effects of CTRP13 on atherosclerosis. In summary, these findings define CTRP13 as a novel approach for preventing atherosclerotic plaque formation\n                    <jats:italic>via<\/jats:italic>\n                    modulation of lipid uptake and foam\u2010cell migration.\u2014Wang, C., Xu, W., Liang, M., Huang, D., Huang, K. CTRP13 inhibits atherosclerosis\n                    <jats:italic>via<\/jats:italic>\n                    autophagy\u2010lysosome\u2013dependent degradation of CD36. FASEB J. 33, 2290\u20132300 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801267rr","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T12:00:29Z","timestamp":1537185629000},"page":"2290-2300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["CTRP13 inhibits atherosclerosis\n                    <i>via<\/i>\n                    autophagy\u2010lysosome\u2010dependent degradation of CD36"],"prefix":"10.1096","volume":"33","author":[{"given":"Cheng","family":"Wang","sequence":"first","affiliation":[{"name":"Clinic Center of Human Gene Research Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Xu","sequence":"additional","affiliation":[{"name":"Clinic Center of Human Gene Research Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglu","family":"Liang","sequence":"additional","affiliation":[{"name":"Clinic Center of Human Gene Research Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinic Center of Human Gene Research Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinic Center of Human Gene Research Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-017-1575-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306256"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008922"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3520"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132620"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v3.i4.345"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02834-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2469"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102808-114910"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-00302-8_1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2016.04.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.023"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2017.32.1.41"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.02.011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.231050"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.201087"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.07.002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062862"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.7754\/Clin.Lab.2016.160609","article-title":"The circulating levels of complement-C1q\/TNF-related protein 13 (CTRP13) in patients with type 2 diabetes and its association with insulin resistance","volume":"63","author":"Afrookhteh A.","year":"2017","journal-title":"Clin. 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