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Previous studies reported aquaporin (AQP)\u20103 expression in cysts derived from collecting ducts in ADPKD. To study the role of AQP3 in cyst development, we generated 2 polycystic kidney disease (PKD) mouse models: kidney\u2010specific\n                    <jats:italic>Pkd1<\/jats:italic>\n                    knockout mice and inducible\n                    <jats:italic>Pkd1<\/jats:italic>\n                    knockout mice, each without and with AQP3 deletion. In both models, kidney sizes and cyst indexes were significantly reduced in AQP3\u2010null PKD mice compared with AQP3\u2010expressing PKD mice, with the difference seen mainly in collecting duct cysts. AQP3\u2010deficient kidneys showed significantly reduced ATP content, increased phosphorylated (p)\u2010AMPK, and decreased p\u2010ERK and p\u2010mammalian target of rapamycin (mTOR). In a matrix\u2010grown Madin\u2010Darby canine kidney cyst model, AQP3 expression promoted cyst enlargement and was associated with increased expression of hypoxia\u2010inducible factor 1\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and glucose transporter 1 and increased glucose uptake. Our data suggest that the slowed renal cyst enlargement in AQP3 deficiency involves impaired energy metabolism in the kidney through AMPK and mTOR signaling and impaired cellular glucose uptake. These findings implicate AQP3 as a novel determinant of renal cyst enlargement and hence a potential drug target in ADPKD.\u2014Wang, W., Geng, X., Lei, L., Jia, Y., Li, Y., Zhou, H., Verkman, A. S., Yang, B. Aquaporin\u20103 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease. FASEB J. 33, 6185\u20136196 (2019).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801338rrr","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T12:45:53Z","timestamp":1550234753000},"page":"6185-6196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Aquaporin\u20103 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease"],"prefix":"10.1096","volume":"33","author":[{"given":"Weiling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Peking University  Beijing China"},{"name":"State Key Laboratory of Natural and Biomimetic Drugs  Beijing China"},{"name":"Beijing Research Institute of Chinese 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