{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:37:14Z","timestamp":1788536234712,"version":"build-2803163510"},"reference-count":158,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease is a progressive, incurable neurodegenerative disease targeting specific neuronal populations within the brain while neighboring neurons appear unaffected. The focus for defining mechanisms has therefore been on the pathogenesis in affected neuronal populations and developing intervention strategies to prevent their cell death. However, there is growing recognition of the importance of glial cells in the development of pathology. Determining exactly how glial cells are involved in the disease process and the susceptibility of the aging brain provides unprecedented challenges. The present review examines recent studies attempting to unravel the glial response during the course of disease and how this action may dictate the outcome of neurodegeneration. The importance of regional heterogeneity of glial cells within the CNS during healthy aging and disease is examined to understand how the glial cells may contribute to neuronal susceptibility or resilience during the neurodegenerative process.\u2014Alibhai, J. D., Diack, A. B., Manson, J. C. Unravelling the glial response in the pathogenesis of Alzheimer's disease. 32, 5766\u20135777 (2018).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201801360r","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T15:06:46Z","timestamp":1540912006000},"page":"5766-5777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Unravelling the glial response in the pathogenesis of Alzheimer's disease"],"prefix":"10.1096","volume":"32","author":[{"given":"James D.","family":"Alibhai","sequence":"first","affiliation":[{"name":"National Creutzfeldt-Jakob Disease (CJD) Research and Surveillance Unit University of Edinburgh Edinburgh United Kingdom"},{"name":"UK Dementia Research Institute University of Edinburgh Edinburgh United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail B.","family":"Diack","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh Roslin United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C.","family":"Manson","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences University of Edinburgh Edinburgh United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Dementia statistics 2018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-017-0077-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-045115"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2017.04.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408900111"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1038\/s41598-018-21641-1","article-title":"Molecular subtypes of Alzheimer's disease","volume":"8","author":"Di Fede G.","year":"2018","journal-title":"Sci. Rep."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.04.047"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1230-17.2017"},{"key":"e_1_2_9_10_1","first-page":"1","article-title":"The prion-like properties of amyloid-\u03b2 assemblies: implications for Alzheimer's disease","volume":"6","author":"Walker L. C.","year":"2016","journal-title":"Cold SpringHarb. Perspect. Med."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0495-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1231-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1747"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071714-033828"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0503-z"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15369"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"w14287","DOI":"10.4414\/smw.2016.14287","article-title":"Amyloid-\u03b2 pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting","volume":"146","author":"Frontzek K.","year":"2016","journal-title":"SwissMed. Wkly."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1588-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1791-x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1703-0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90168-X"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.02.031"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4547"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0488-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.08.166"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201601184"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002579"},{"key":"e_1_2_9_28_1","first-page":"1","article-title":"Die diagnostischen schwierigkeiten in der psychiatrie","volume":"1","author":"Alzheimer A.","year":"1910","journal-title":"Arch. Psychiatr. Nervenkr. Z GesamteNeurol. Psychiatr."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90229-W"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.11.006"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110647"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2010"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.030"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22409"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22633"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2016.05.001"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.06.020"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1472"},{"key":"e_1_2_9_39_1","first-page":"066001","article-title":"In vivo two-photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes","volume":"9","author":"Kozai T. D.","year":"2012","journal-title":"J. NeuralEng."},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.17"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2448"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.006"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2741\/2692"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90606"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MR0416-204R"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-6-45"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-00549-7_8"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/382685a0"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1698-16.2016"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.11.012"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-50"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.04.004"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-73"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903833"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00030-1"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20643-3"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0023-4"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-013-0382-8"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-4-26"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21087"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1715"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv379"},{"key":"e_1_2_9_63_1","first-page":"792","article-title":"An early and late peak in microglial activation in Alzheimer's disease trajectory","volume":"140","author":"Fan Z.","year":"2017","journal-title":"Brain"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12445"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7176"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww017"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.018"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22295"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12522"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1815-1"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.3895"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.135"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.032"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.07.003"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8373"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4132"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11729"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22966"},{"key":"e_1_2_9_80_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer's disease","volume":"217","author":"Hansen D. V.","year":"2018","journal-title":"J. CellBiol."},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211851"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211103"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142322"},{"key":"e_1_2_9_84_1","doi-asserted-by":"crossref","first-page":"11118","DOI":"10.1038\/s41598-017-11634-x","article-title":"TREM2 promotes A\u00df phagocytosis by upregulating C\/EBP\u03b1-dependent CD36 expression in microglia","volume":"7","author":"Kim S. M.","year":"2017","journal-title":"Sci. Rep."},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.049"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.04.014"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.10.004"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X06000202"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4707-08.2009"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-01-00183.2002"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.09.035"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.02.004"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199204010-00005"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1966.29.4.768"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00289.x"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3790-08.2009"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00340.2007"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.01.023"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1967852"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90362-X"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0790-07.2007"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.09.049"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400512"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2007-11113"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20130017"},{"key":"e_1_2_9_106_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2010.03.008","article-title":"Glutamate transporter variants reduce glutamate uptake in Alzheimer' disease","volume":"32","author":"Scott H. A.","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn040"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/34651"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1208-1365"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02443.2002"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2660-04.2004"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3965-04.2005"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.029"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00220"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4466-06.2007"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059162"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.12.1118"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140626.48118.0A"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2012.01536.x"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20967"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20110025"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1358-07.2007"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.01.005"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0601-5"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2015.1025778"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0515-3"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.03.003"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23166"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22658"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2012.09.006"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400784"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20734"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.02.007"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0657-2"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22432"},{"key":"e_1_2_9_136_1","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/glia.20663","article-title":"Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS","volume":"56","author":"DeHaas A.H.","year":"2008","journal-title":"Glia"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4222"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.011"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4597"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3222"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.06.029"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.07.008"},{"key":"e_1_2_9_143_1","first-page":"269","article-title":"The aging astrocyte transcriptome from multiple regions of the mouse brain","volume":"22","author":"Boisvert M. M.","year":"2018","journal-title":"CellRep."},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0840-7"},{"key":"e_1_2_9_145_1","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1128\/JVI.02613-15","article-title":"Defining the microglia response during the time course of chronic neurodegeneration","volume":"90","author":"Vincenti J. E.","year":"2015","journal-title":"J. Virol."},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11295"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.07.007"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.03.021"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.04.013"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22290"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.156"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm452"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.030"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.066"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4303-03.2004"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23986"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63331-7"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2745-14.2015"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.04.047"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201801360R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201801360R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201801360R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:34:39Z","timestamp":1761672879000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201801360R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,10]]},"references-count":158,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1096\/fj.201801360R"],"URL":"https:\/\/doi.org\/10.1096\/fj.201801360r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,10]]},"assertion":[{"value":"2018-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}